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oai:docta.ucm.es:20.500.14352/727972024-10-11T15:06:58Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Fernández Albarral, José author García Martín, Elena Salobrar author Matamoros Felipe, José Antonio author Fernández Mendivil, Cristina author Sastre, Eric, del author Chen, Leijing author Hoz Montañana, María Rosa De author López Cuenca, Inés author Sánchez-Puebla Fernández, Lidia author Ramírez Sebastián, José Manuel author Salazar Corral, Juan José author García López, Manuela author Ramírez Sebastián, Ana Isabel 2023-06-22T12:32:44Z 2023-06-22T12:32:44Z 2022-10-30 Fernández-Albarral, J. A., García Martín, E. S., Matamoros, J. A. et al. «Microglial Hemoxygenase-1 Deletion Reduces Inflammation in the Retina of Old Mice with Tauopathy». Antioxidants, vol. 11, n.o 11, octubre de 2022, p. 2151. DOI.org (Crossref), https://doi.org/10.3390/antiox11112151. 2076-3921 10.3390/antiox11112151 https://hdl.handle.net/20.500.14352/72797 https://doi.org/10.3390/antiox11112151 https://www.mdpi.com/2076-3921/11/11/2151 Tauopathies such as Alzheimer’s disease are characterized by the accumulation of neurotoxic aggregates of tau protein. With aging and, especially, in Alzheimer’s patients, the inducible enzyme heme oxygenase 1 (HO-1) progressively increases in microglia, causing iron accumulation, neuroinflammation, and neurodegeneration. The retina is an organ that can be readily accessed and can reflect changes that occur in the brain. In this context, we evaluated how the lack of microglial HO-1, using mice that do not express HO-1 in microglia (HMO-KO), impacts retinal macro and microgliosis of aged subjects (18 months old mice) subjected to tauopathy by intrahippocampal delivery of AAV-hTauP301L (TAU). Our results show that although tauopathy, measured as anti-TAUY9 and anti-AT8 positive immunostaining, was not observed in the retina of WT-TAU or HMO-KO+TAU mice, a morphometric study of retinal microglia and macroglia showed significant retinal changes in the TAU group compared to the WT group, such as: (i) increased number of activated microglia, (ii) retraction of microglial processes, (iii) increased number of CD68+ microglia, and (iv) increased retinal area occupied by GFAP (AROA) and C3 (AROC3). This retinal inflammatory profile was reduced in HMO-KO+TAU mice. Conclusion: Reduction of microglial HO-1 could be beneficial to prevent tauopathy-induced neuroinflammation. eng Attribution 4.0 International Microglial Hemoxygenase-1 Deletion Reduces Inflammation in the Retina of Old Mice with Tauopathy journal article URL https://docta.ucm.es/bitstreams/d25356b2-fdec-41dd-b919-cdf3fd86d3db/download File MD5 5aad5f90c15defc53b15b2d651c38638 8272852 application/pdf antioxidants-11-02151.pdf URL https://docta.ucm.es/bitstreams/abe7bf8d-d3f3-409e-b097-2cfbf5762bad/download File MD5 861cfc3272155a581b5f530ba9e129c6 109731 text/plain antioxidants-11-02151.pdf.txt