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oai:docta.ucm.es:20.500.14352/731732023-08-27T08:55:20Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Cirillo, Giovanni author Negrete Díaz, Flor author Yucuma, Daniela author Virtuoso, Assunta author Sohaib, Korai Ali author De Luca, Ciro author Kaniusas, Eugenijus author Papa, Michele author Panetsos Petrova, Fivos author 2022-12-17 Inflammatory bowel diseases, including Crohn’s disease and ulcerative colitis, are incurable autoimmune diseases characterized by chronic inflammation of the gastrointestinal tract. There is increasing evidence that inappropriate interaction between the enteric nervous system and central nervous system and/or low activity of the vagus nerve, which connects the enteric and central nervous systems, could play a crucial role in their pathogenesis. Therefore, it has been suggested that appropriate neuroprosthetic stimulation of the vagus nerve could lead to the modulation of the inflammation of the gastrointestinal tract and consequent long-term control of these autoimmune diseases. In the present paper, we provide a comprehensive overview of (1) the cellular and molecular bases of the immune system, (2) the way central and enteric nervous systems interact and contribute to the immune responses, (3) the pathogenesis of the inflammatory bowel disease, and (4) the therapeutic use of vagus nerve stimulation, and in particular, the transcutaneous stimulation of the auricular branch of the vagus nerve. Then, we expose the working hypotheses for the modulation of the molecular processes that are responsible for intestinal inflammation in autoimmune diseases and the way we could develop personalized neuroprosthetic therapeutic devices and procedures in favor of the patients. 2073-4409 10.3390/cells11244103 https://hdl.handle.net/20.500.14352/73173 https://doi.org/10.3390/cells11244103 https://www.mdpi.com/2073-4409/11/24/4103 Vagus Nerve Stimulation: A Personalized Therapeutic Approach for Crohn’s and Other Inflammatory Bowel Diseases