2026-06-08T02:44:02Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/731732023-08-27T08:55:20Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Cirillo, Giovanni author Negrete Díaz, Flor author Yucuma, Daniela author Virtuoso, Assunta author Sohaib, Korai Ali author De Luca, Ciro author Kaniusas, Eugenijus author Papa, Michele author Panetsos Petrova, Fivos 2023-06-22T12:46:58Z 2023-06-22T12:46:58Z 2022-12-17 2073-4409 10.3390/cells11244103 https://hdl.handle.net/20.500.14352/73173 https://doi.org/10.3390/cells11244103 https://www.mdpi.com/2073-4409/11/24/4103 Inflammatory bowel diseases, including Crohn’s disease and ulcerative colitis, are incurable autoimmune diseases characterized by chronic inflammation of the gastrointestinal tract. There is increasing evidence that inappropriate interaction between the enteric nervous system and central nervous system and/or low activity of the vagus nerve, which connects the enteric and central nervous systems, could play a crucial role in their pathogenesis. Therefore, it has been suggested that appropriate neuroprosthetic stimulation of the vagus nerve could lead to the modulation of the inflammation of the gastrointestinal tract and consequent long-term control of these autoimmune diseases. In the present paper, we provide a comprehensive overview of (1) the cellular and molecular bases of the immune system, (2) the way central and enteric nervous systems interact and contribute to the immune responses, (3) the pathogenesis of the inflammatory bowel disease, and (4) the therapeutic use of vagus nerve stimulation, and in particular, the transcutaneous stimulation of the auricular branch of the vagus nerve. Then, we expose the working hypotheses for the modulation of the molecular processes that are responsible for intestinal inflammation in autoimmune diseases and the way we could develop personalized neuroprosthetic therapeutic devices and procedures in favor of the patients. eng Atribución 3.0 España Vagus Nerve Stimulation: A Personalized Therapeutic Approach for Crohn’s and Other Inflammatory Bowel Diseases journal article URL https://docta.ucm.es/bitstreams/08cd4a29-1a51-4547-aa04-483f6ff61cc1/download File MD5 786bfafea35de62fe53d399e7298836c 3049982 application/pdf Vagus_Nerve_Stimulation_A_Per.pdf URL https://docta.ucm.es/bitstreams/f55df121-06be-4b30-a3fd-936151e9f876/download File MD5 b7b9e653b5876465815dc58e8b25515b 134060 text/plain Vagus_Nerve_Stimulation_A_Per.pdf.txt