2026-06-29T03:08:08Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/732162024-04-08T17:07:02Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense
author
Hecker, Yanina Paola
author
Burucúa, Mercedes M.
author
Fiorani, Franco
author
Maldonado Rivera, Jaime E.
author
Cirone, Karina M.
author
Dorsch, Matías A.
author
Cheuquepán, Felipe A.
author
Campero, Lucía M.
author
Cantón, Germán J.
author
Marín, Maia S.
author
Ortega Mora, Luis Miguel
author
Moore, Dadín P.
2023-06-22T12:49:06Z
2023-06-22T12:49:06Z
2022-07-25
2076-393X
10.3390/vaccines10081175
https://hdl.handle.net/20.500.14352/73216
https://doi.org/10.3390/vaccines10081175
https://www.mdpi.com/2076-393X/10/8/1175
Neospora caninum is recognised for causing cattle abortion, provoking severe economic losses in the livestock industry worldwide. The aim of the present study was to evaluate the reactivation and foetal infection in pregnant heifers inoculated with live N. caninum tachyzoites before puberty. A total of 15 30-month-old pregnant heifers were allocated into four groups: animals inoculated with live tachyzoites of NC-Argentina LP1 isolate before puberty and challenged with live tachyzoites of NC-1 strain at 210 days of gestation (DG) (Group A); animals mock inoculated before puberty and challenged with NC-1 strain at 210 DG (Group B), animals inoculated before puberty but not subsequently challenged (Group C); and noninfected and nonchallenged animals (Group D). The results of this study showed that 100% of animals infected before puberty (Groups A and C) suffered reactivation of the infection at the seventh month of gestation. In addition, in three and two calves from Groups A and C, respectively, congenital infection was confirmed. Interestingly, we provide evidence that the use of live N. caninum tachyzoites in young animals as a strategy to induce protection is neither safe nor effective.
eng
Atribución 3.0 España
Reactivation and Foetal Infection in Pregnant Heifers Infected with Neospora caninum Live Tachyzoites at Prepubertal Age
journal article
URL
https://docta.ucm.es/bitstreams/207d6a26-be57-4d8a-8534-9cb95910ab4d/download
File
MD5
57508f38d1b169c62d81e0a483e80d4b
1892054
application/pdf
vaccines-10-01175-v2.pdf
URL
https://docta.ucm.es/bitstreams/d37c1860-f6c5-46e3-ac03-d94f264aa140/download
File
MD5
8ddabcb9171d409cb4f40bf91961f5fd
68373
text/plain
vaccines-10-01175-v2.pdf.txt