2026-06-27T22:43:00Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/733062025-01-20T17:13:00Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense
author
Benhamú Salama, Bellinda
author
Martín-Fontecha Corrales, María Del Mar
author
Vázquez Villa, María Del Henar
author
López Rodríguez, María Luz
author
Ortega Gutiérrez, Silvia
2023-06-22T12:53:59Z
2023-06-22T12:53:59Z
2022-08-15
2227-9059
10.3390/biomedicines10082006
https://hdl.handle.net/20.500.14352/73306
https://doi.org/10.3390/biomedicines10082006
https://www.mdpi.com/2227-9059/10/8/2006
Aging is considered the main risk factor for many chronic diseases that frequently appear at advanced ages. However, the inevitability of this process is being questioned by recent research that suggests that senescent cells have specific features that differentiate them from younger cells and that removal of these cells ameliorates senescent phenotype and associated diseases. This opens the door to the design of tailored therapeutic interventions aimed at reducing and delaying the impact of senescence in life, that is, extending healthspan and treating aging as another chronic disease. Although these ideas are still far from reaching the bedside, it is conceivable that they will revolutionize the way we understand aging in the next decades. In this review, we analyze the main and well-validated cellular pathways and targets related to senescence as well as their implication in aging-associated diseases. In addition, the most relevant small molecules with senotherapeutic potential, with a special emphasis on their mechanism of action, ongoing clinical trials, and potential limitations, are discussed. Finally, a brief overview of alternative strategies that go beyond the small molecule field, together with our perspectives for the future of the field, is provided.
eng
Atribución 3.0 España
New Trends in Aging Drug Discovery
journal article
URL
https://docta.ucm.es/bitstreams/63d043f6-89c2-4d21-9438-eecbfdd49abf/download
File
MD5
9dd3a40084762eb51ba66e2e3e281a8c
2646886
application/pdf
biomedicines-10-02006-v2.pdf
URL
https://docta.ucm.es/bitstreams/3937681d-f6fe-4fdc-bd12-d3baeb64e679/download
File
MD5
026bb1c111ba3ccfc06ddec86885c86a
127737
text/plain
biomedicines-10-02006-v2.pdf.txt