2026-06-27T12:39:52Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/733362023-08-25T20:07:20Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Serramito Blanco, María author Pereira da Mota, Ana Filipa author Carpena Torres, Carlos author Huete Toral, Fernando author Álvarez Lorenzo, Carmen Isabel author Carracedo Rodríguez, Juan Gonzalo author 2022-05 Background: The purpose of this study was to synthesize melatonin-eluting contact lenses (CLs) and evaluate both the ocular kinetics of the released melatonin and its effect on tear volume and intraocular pressure. Methods: In vitro, melatonin-eluting CLs were synthesized by using non-functionalized (HEMA) and functionalized (HEMA/APMA) monomers. In vivo, a short-term prospective and randomized study was performed on 15 rabbits divided into two groups: 12 rabbits wearing functionalized CLs and 3 rabbits without CLs as a control. The melatonin levels in tears, aqueous humor, vitreous body and retina, tear volume, and intraocular pressure were measured for 8 h. Results: In vitro, both monomers did not show differences in terms of melatonin loading and release (p ≥ 0.05). In vivo, the melatonin concentration was elevated in tears and aqueous humor after 2 and 4 h of wearing CLs, respectively (p < 0.05). Additionally, the CLs increased tear volume for 2 h (p < 0.05). Conclusions: The melatonin-eluting CLs released their content over the ocular surface for at least 2 h, which was associated with a secretagogue effect on tear volume. However, the increased amount of melatonin found in the aqueous humor had no effect on intraocular pressure. 1999-4923 10.3390/pharmaceutics14051019 https://hdl.handle.net/20.500.14352/73336 https://doi.org/10.3390/pharmaceutics14051019 https://www.mdpi.com/1999-4923/14/5/1019 Melatonin-Eluting Contact Lenses Effect on Tear Volume: In Vitro and In Vivo Experiments