2026-06-26T16:05:09Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/733362023-08-25T20:07:20Zcom_20.500.14352_14col_20.500.14352_15

Serramito Blanco, María Pereira da Mota, Ana Filipa Carpena Torres, Carlos Huete Toral, Fernando Álvarez Lorenzo, Carmen Isabel Carracedo Rodríguez, Juan Gonzalo 2023-06-22T12:55:45Z 2023-06-22T12:55:45Z 2022-05 1999-4923 10.3390/pharmaceutics14051019 https://hdl.handle.net/20.500.14352/73336 https://doi.org/10.3390/pharmaceutics14051019 https://www.mdpi.com/1999-4923/14/5/1019 Background: The purpose of this study was to synthesize melatonin-eluting contact lenses (CLs) and evaluate both the ocular kinetics of the released melatonin and its effect on tear volume and intraocular pressure. Methods: In vitro, melatonin-eluting CLs were synthesized by using non-functionalized (HEMA) and functionalized (HEMA/APMA) monomers. In vivo, a short-term prospective and randomized study was performed on 15 rabbits divided into two groups: 12 rabbits wearing functionalized CLs and 3 rabbits without CLs as a control. The melatonin levels in tears, aqueous humor, vitreous body and retina, tear volume, and intraocular pressure were measured for 8 h. Results: In vitro, both monomers did not show differences in terms of melatonin loading and release (p ≥ 0.05). In vivo, the melatonin concentration was elevated in tears and aqueous humor after 2 and 4 h of wearing CLs, respectively (p < 0.05). Additionally, the CLs increased tear volume for 2 h (p < 0.05). Conclusions: The melatonin-eluting CLs released their content over the ocular surface for at least 2 h, which was associated with a secretagogue effect on tear volume. However, the increased amount of melatonin found in the aqueous humor had no effect on intraocular pressure. eng https://creativecommons.org/licenses/by/3.0/es/ open access Atribución 3.0 España Melatonin-Eluting Contact Lenses Effect on Tear Volume: In Vitro and In Vivo Experiments journal article