2026-07-20T08:54:46Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/73602023-08-05T23:39:06Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense
author
Giuppi, Martina
author
La Salvia, Anna
author
Evangelista, Jessica
author
Ghidini, Michele
2023-06-17T08:31:28Z
2023-06-17T08:31:28Z
2021
2079-7737
10.3390/biology10020146
https://hdl.handle.net/20.500.14352/7360
https://doi.org/10.3390/biology10020146
https://www.mdpi.com/2079-7737/10/2/146https://www.mdpi.com/journal/biology
Gastric cancer (GC) is the fifth most frequently diagnosed malignant tumor and the third highest cause of cancer mortality worldwide. For advanced GC, many novel drugs and combinations have been tested, but results are still disappointing, and the disease is incurable in the majority of cases. In this regard, it is critical to investigate the molecular mechanisms underlying GC development. Angiogenesis is one of the hallmarks of cancer with a fundamental role in GC growth and progression. Ramucirumab, a monoclonal antibody that binds to vascular endothelial growth factor-2 (VEGFR-2), is approved in the treatment of advanced and pretreated GC. However, no predictive biomarkers for ramucirumab have been identified so far. Micro RNAs (miRNAs) are a class of evolutionarily-conserved single-stranded non-coding RNAs that play an important role (via post-transcriptional regulation) in essentially all biologic processes, such as cell proliferation, differentiation, apoptosis, survival, invasion, and migration. In our review, we aimed to analyze the available data on the role of angiogenesis-related miRNAs in GC.
eng
Atribución 3.0 España
The Role and Expression of Angiogenesis-Related miRNAs in Gastric Cancer
journal article
URL
https://docta.ucm.es/bitstreams/22cf51ad-3865-48e8-a2b1-0ec84936f7ce/download
File
MD5
21118644958a28c340d35758e447171e
10111341
application/pdf
biology-10-00146.pdf