2026-06-27T22:46:11Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/73652024-10-11T14:20:48Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Pérez García, Carlos Nicolás author Enríquez Vázquez, Daniel author Méndez Bailón, Manuel author Olmos, Carmen author Gómez Polo, Juan Carlos author Iguarán Bermúdez, Rosario author Ramos López, Noemí author García Klepzig, José Luis author Ferrández Escarabajal, Marcos author Jerónimo, Adrián author Martínez Gómez, Eduardo author Font Urgelles, Judit author Fragiel Saavedra, Marcos author Paz Arias, Pilar author Romero Delgado, Teresa author Gómez Álvarez, Zaira author Playán Escribano, Julia author Jaén, Esther author Vargas, Gianna author González, Elizabeth author Orviz, Eva author Burruezo, Irene author Calvo, Alberto author Nieto Sánchez, Ángel author Molino González, Ángel Manuel author Lorenzo Villalba, Noel author Andrès, Emmanuel author Macaya, Carlos author Vila Costa, Isidro 2023-06-17T08:31:35Z 2023-06-17T08:31:35Z 2021 2077-0383 10.3390/jcm10040825 https://hdl.handle.net/20.500.14352/7365 https://doi.org/10.3390/jcm10040825 https://www.mdpi.com/2077-0383/10/4/825https://www.mdpi.com/journal/jcm Introduction: The worldwide pandemic, coronavirus disease 2019 (COVID-19) is a novel infection with serious clinical manifestations, including death. Our aim is to describe the first non-ICU Spanish deceased series with COVID-19, comparing specifically between unexpected and expected deaths. Methods: In this single-centre study, all deceased inpatients with laboratory-confirmed COVID-19 who had died from March 4 to April 16, 2020 were consecutively included. Demographic, clinical, treatment, and laboratory data, were analyzed and compared between groups. Factors associated with unexpected death were identified by multivariable logistic regression methods. Results: In total, 324 deceased patients were included. Median age was 82 years (IQR 76–87); 55.9% males. The most common cardiovascular risk factors were hypertension (78.4%), hyperlipidemia (57.7%), and diabetes (34.3%). Other common comorbidities were chronic kidney disease (40.1%), chronic pulmonary disease (30.3%), active cancer (13%), and immunosuppression (13%). The Confusion, BUN, Respiratory Rate, Systolic BP and age ≥65 (CURB-65) score at admission was >2 in 40.7% of patients. During hospitalization, 77.8% of patients received antivirals, 43.3% systemic corticosteroids, and 22.2% full anticoagulation. The rate of bacterial co-infection was 5.5%, and 105 (32.4%) patients had an increased level of troponin I. The median time from initiation of therapy to death was 5 days (IQR 3.0–8.0). In 45 patients (13.9%), the death was exclusively attributed to COVID-19, and in 254 patients (78.4%), both COVID-19 and the clinical status before admission contributed to death. Progressive respiratory failure was the most frequent cause of death (92.0%). Twenty-five patients (7.7%) had an unexpected death. Factors independently associated with unexpected death were male sex, chronic kidney disease, insulin-treated diabetes, and functional independence. Conclusions: This case series provides in-depth characterization of hospitalized non-ICU COVID-19 patients who died in Madrid. Male sex, insulin-treated diabetes, chronic kidney disease, and independency for activities of daily living are predictors of unexpected death. eng Atribución 3.0 España The SADDEN DEATH Study: Results from a Pilot Study in Non-ICU COVID-19 Spanish Patients journal article URL https://docta.ucm.es/bitstreams/75c0297a-ea1d-430d-b47c-999ccf6eb7e9/download File MD5 6a7d3dedde9e88a94a20e22a3ce57820 2988734 application/pdf jcm-10-00825.pdf