2026-06-26T10:42:09Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/74032023-08-26T12:58:36Zcom_20.500.14352_14col_20.500.14352_15

Virological Correlates of IgM–IgG Patterns of Response to SARS-CoV-2 Infection According to Targeted Antigens Barreiro, Pablo Candel González, Francisco Javier Sanz, Juan Carlos San Román Montero, Jesús del Mar Carretero, María Pérez Abeledo, Marta Ramos, Belén Viñuela Prieto, José Manuel Canora, Jesús Martínez Peromingo, Francisco Javier Zapatero, Antonio The virological meaning of the different patterns of serology in COVID-19 has been little examined in clinical settings. Asymptomatic subjects with IgM-spike (S) and IgG-nucleocapsid (N) determinations by chemiluminescence were studied for SARS-CoV-2 shedding in respiratory secretions by transcription-mediated amplification (TMA). In subjects showing IgM-S positive and IgG-N negative, IgG-S was determined by lateral flow assay. A total of 712 individuals were tested: 30.0% presented IgM-S(+)/IgG-N(−), 25.8% had IgM-S(+)/IgG-N(+) and 44.2% had IgM-S(−)/IgG-N(+); the proportion with TMA(+) were comparable in these three groups: 12.1, 8.7 and 10.5%, respectively. In individuals with IgM-S(+)/IgG-N(−), IgG-S(+) was detected in 66.5%. The frequency of IgM-S(+)/IgG-S(−) in the total population was 10.0%, of whom 24.1% had TMA(+); the chances for TMA(+) in subjects with an IgM-S(+) alone pattern were 2.4%. Targeting of the same SARS-CoV-2 antigen seems to be better for the characterization of IgM/IgG patterns of response. IgM-S(+) alone reactivity is rare, and a small proportion is associated with viral shedding. 2023-06-17T08:32:34Z 2023-06-17T08:32:34Z 2023-06-17T08:32:34Z 2021-05-10 journal article https://hdl.handle.net/20.500.14352/7403 1999-4915 10.3390/v13050874 eng https://creativecommons.org/licenses/by/3.0/es/ open access Atribución 3.0 España MDPI