2026-06-08T02:37:52Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/74322023-08-27T11:22:45Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Romero Martínez, Manuel Alejandro author Ramos Alonso, Eva author López Muñoz, Francisco author Ríos, Cristóbal de los author Egea, Javier author Gil Martín, Emilio author Pita Pita, Rene author Torrado Durán, Juan José author Serrano López, Dolores Remedios author Juberias, Antonio author 2021-04-10 Blister or vesicant chemical warfare agents (CWAs) have been widely used in different military conflicts, including World War I and the Iran-Iraq War. However, their mechanism of action is not fully understood. Sulfur and nitrogen mustard exert toxic effects not only through the alkylation of thiol-bearing macromolecules, such as DNA and proteins, but also produce free radicals that can develop direct toxic effects in target organs such as the eyes, skin, and respiratory system. The lack of effective treatments against vesicant CWAs-induced injury makes us consider, in this complex scenario, the use and development of melatonin-based therapeutic strategies. This multifunctional indoleamine could facilitate neutralization of the oxidative stress, modulate the inflammatory response, and prevent the DNA damage, as well as the long-term health consequences mediated by vesicant CWAs-induced epigenetic mechanisms. In this context, it would be essential to develop new galenic formulations for the use of orally and/or topically applied melatonin for the prophylaxis against vesicant CWAs, as well as the development of post-exposure treatments in the near future. 2079-9721 10.3390/diseases9020027 https://hdl.handle.net/20.500.14352/7432 https://www.mdpi.com/journal/diseases Toxicology of Blister Agents: Is Melatonin a Potential Therapeutic Option?