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Docta Complutense author Crespo, Pascual Vicente author Campos, Fernando author Leal, Manuel author Maraver Eyzaguirre, Francisco De Paula 2023-06-17T08:34:01Z 2023-06-17T08:34:01Z 2021 Crespo, P. V., Campos, F., Leal, M. & Maraver Eyzaguirre, F. P. «Effects of Sodium Chloride-Rich Mineral Water on Intestinal Epithelium. Experimental Study». International Journal of Environmental Research and Public Health, vol. 18, n.o 6, marzo de 2021, p. 3261. Crossref, https://doi.org/10.3390/ijerph18063261. 1660-4601 10.3390/ijerph18063261 https://hdl.handle.net/20.500.14352/7455 https://doi.org/10.3390/ijerph18063261 https://www.mdpi.com/1660-4601/18/6/3261 Since knowledge concerning the cellular and tissue substrate that explains the therapeutic action of mineral waters is generally very scarce, we address the different effects that Lanjarón-Capuchina mineral water exerts on the intestinal epithelium in an experimental model as a prototype of the sodium chloride-rich mineral waters used in digestive disorders. In the experimental protocol, two groups of five adult Wistar rats received unrestricted mineral water in their diet or mineral water directly into the gastrointestinal tract through a catheter. A third control group was given a standard diet and water ad libitum. Intestinal samples for scanning electron microscopy were analyzed according to standardized methods. The observations carried out by microscope after the administration of the sodium chloride-rich mineral water clearly indicate that the hypertonic action of this mineral water affects the structure of the intestinal epithelium. It modifies the microvilli absorption in terms of the groups of enterocytes and the secretion of goblet cells, but it particularly affects the epithelial renewal process, accelerating and stimulating cell extrusion. The type of extrusion mechanism observed by microscope allows us to affirm that, although this increased after direct administration, it does not generate an epithelial disruption as it occurs in other circumstances with other extrusion modalities. eng Atribución 3.0 España Effects of Sodium Chloride-Rich Mineral Water on Intestinal Epithelium. Experimental Study journal article URL https://docta.ucm.es/bitstreams/febcd29b-42bf-484c-b6d2-29c902a92a70/download File MD5 edd608db754fe453008b739bd9fa3de3 925265 application/pdf ijerph-18-03261.pdf