2026-06-29T02:13:34Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/74872023-07-19T05:24:02Zcom_20.500.14352_14col_20.500.14352_15

Effects of Substituents on Photophysical and CO-Photoreleasing Properties of 2,6-Substituted meso-Carboxy BODIPY Derivatives † Sánchez-Carnerero, Esther M. Russo, Marina Jakob, Andreas Muchová, Lucie Vítek, Libor Klán, Petr 577.1 BODIPY photochemistry carbon monoxide photorelease carbon monoxide-releasing molecules Bioquímica (Química) Carbon monoxide (CO) is an endogenously produced signaling molecule involved in the control of a vast array of physiological processes. One of the strategies to administer therapeutic amounts of CO is the precise spatial and temporal control over its release from photoactivatable CO-releasing molecules (photoCORMs). Here we present the synthesis and photophysical and photochemical properties of a small library of meso-carboxy BODIPY derivatives bearing different substituents at positions 2 and 6. We show that the nature of substituents has a major impact on both their photophysics and the efficiency of CO photorelease. CO was found to be efficiently released from π-extended 2,6-arylethynyl BODIPY derivatives possessing absorption spectra shifted to a more biologically desirable wavelength range. Selected photoCORMs were subjected to in vitro experiments that did not reveal any serious toxic effects, suggesting their potential for further biological research. Czech Science Foundation Czech Ministry of Health Czech Ministry of Education, Youth, and Sports RECETOX research infrastructure Depto. de Bioquímica y Biología Molecular Fac. de Ciencias Químicas TRUE pub 2023-06-17T08:34:57Z 2023-06-17T08:34:57Z 2021 journal article https://hdl.handle.net/20.500.14352/7487 2624-8549 10.3390/chemistry3010018 eng (GA18-12477S) (RVO–VFN64165/2020, L.V.) (CZ.02.1.01/0.0/0.0/17_043/0009632 and EU H2020: 857560) (LM2018121) Atribución 3.0 España https://creativecommons.org/licenses/by/3.0/es/ open access application/pdf MDPI