2026-06-27T11:27:44Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/75382024-09-16T14:28:55Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense
author
García Martín, Elena Salobrar
author
Méndez Hernández, Carmen Dora
author
Hoz Montañana, María Rosa De
author
Ramírez Sebastián, Ana Isabel
author
López Cuenca, Inés
author
Fernández Arrabal, José A.
author
Rojas Lozano, María Del Pilar
author
Wang, Surina
author
García Feijoo, Julián
author
Gil Gregorio, Pedro
author
Salazar Corral, Juan José
author
Ramírez Sebastián, José Manuel
2023-06-17T08:55:51Z
2023-06-17T08:55:51Z
2020
Salobrar García, E., S., Menéndez Hernández, C. D., Hoz Montañana, M. R. et al. «Ocular Vascular Changes in Mild Alzheimer’s Disease Patients: Foveal Avascular Zone, Choroidal Thickness, and ONH Hemoglobin Analysis». Journal of Personalized Medicine, vol. 10, n.o 4, noviembre de 2020, p. 231. DOI.org (Crossref), https://doi.org/10.3390/jpm10040231.
2075-4426
10.3390/jpm10040231
https://hdl.handle.net/20.500.14352/7538
https://doi.org/10.3390/jpm10040231
https://www.mdpi.com/2075-4426/10/4/231
In Alzheimer’s disease (AD), vascular changes could be caused by amyloid beta (Aβ) aggregates replacing the contractile smooth musculature of the arteriole walls. These changes happen in the brain vascular network, but also in the eye, and are related to decreased vascular density and low blood flow. In patients with Alzheimer’s disease, thinning of the choroid and the retina has been shown. The aim of this prospective study was to assess the retinal and choroidal vascular systems, analyzing the choroidal thickness with optical coherence tomography (OCT), the foveal avascular zone (FAZ) with OCT-angiography (OCTA), and the optic nerve head (ONH) hemoglobin with the Laguna ONhE program, to evaluate which of the two ocular vascular systems shows earlier changes in mild AD patients. These patients, compared to controls, showed a significantly thinner choroid at all the analyzed points, with the exception of the temporal macula (at 1000 and 1500 µm from the fovea). On the other hand, the FAZ and ONH hemoglobin did not show significant differences. In conclusion, a thinner choroid was the main ocular vascular change observed in mild AD patients, while the retinal vessels were not yet affected. Therefore, choroidal thickness could be used an early biomarker in AD.
eng
Atribución 3.0 España
Ocular Vascular Changes in Mild Alzheimer’s Disease Patients: Foveal Avascular Zone, Choroidal Thickness, and ONH Hemoglobin Analysis
journal article
URL
https://docta.ucm.es/bitstreams/245818f7-69bd-41ba-959b-f083dc8b6a6f/download
File
MD5
f9c2d4cfc4c841954294ef05e2f5a500
1060738
application/pdf
Salazar_2020_jpm-10-00231.pdf