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00925njm 22002777a 4500 dc Jiménez Holguín, Javier author López Hidalgo, Álvaro author Sánchez Salcedo, Sandra author Peña Martínez, Juan author Vallet Regí, María Dulce Nombre author Salinas Sánchez, Antonio Jesús author 2020-12-03 In the search of a new biomaterial for the treatment of bone defects resulting from traumatic events, an osteoporosis scenario with bone fractures, tumor removal, congenital pathologies or implant revisions for infection, we developed 3D scaffolds based on mesoporous bioactive glasses (MBGs) (85−x)SiO2–5P2O5–10CaO–xSrO (x = 0, 2.5 and 5 mol.%). The scaffolds with meso-macroporosity were fabricated by pouring a suspension of MBG powders in polyvinyl alcohol (PVA) into a negative template of polylactic acid (PLA), followed by removal of the template by extraction at low temperature. SrO-containing MBGs exhibited excellent properties for bone substitution including ordered mesoporous structure, high textural properties, quick in vitro bioactive response in simulated body fluid (SBF) and the ability of releasing concentrations of strontium ions able to stimulate expression of early markers of osteoblastic differentiation. Moreover, the direct contact of MC3T3-E1 pre-osteoblastic cells with the scaffolds confirmed the cytocompatibility of the three compositions investigated. Nevertheless, the scaffold containing 2.5% of SrO induced the best cellular proliferation showing the potential of this scaffold as a candidate to be further investigated in vitro and in vivo, aiming to be clinically used for bone regeneration applications in non-load bearing sites. Jiménez Holguín, J., López Hidalgo, Á., Sánchez Salcedo, S. et al. «Strontium-Modified Scaffolds Based on Mesoporous Bioactive Glasses/Polyvinyl Alcohol Composites for Bone Regeneration». Materials, vol. 13, n.o 23, diciembre de 2020, p. 5526. DOI.org (Crossref), https://doi.org/10.3390/ma13235526. 1996-1944 10.3390/ma13235526 https://hdl.handle.net/20.500.14352/7577 https//doi.org/10.3390/ma13235526 https://www.ucm.es/valletregigroup https://www.mdpi.com/journal/materials Strontium-Modified Scaffolds Based on Mesoporous Bioactive Glasses/Polyvinyl Alcohol Composites for Bone Regeneration