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Docta Complutense author Lifante Cañavate, José author Shen, Yingli author Zabala Gutiérrez, Irene author Rubia Rodríguez, Irene author Ortega, Daniel author Fernández Monsalve, Nuria author Melle Hernández, Sonia author Granado García, Miriam author Rubio Retama, Benito Jorge author Jaque García, Daniel author Ximendes, Erving Clayton 2023-06-17T09:00:16Z 2023-06-17T09:00:16Z 2021-03-03 Lifante Cañavete, J., Shen, Y., Zabala Gutiérrez, I. et al. «Reaching Deeper: Absolute In Vivo Thermal Reading of Liver by Combining Superbright Ag 2 S Nanothermometers and In Silico Simulations». Advanced Science, vol. 8, n.o 9, mayo de 2021, p. 2003838. DOI.org (Crossref), https://doi.org/10.1002/advs.202003838. 2198-3844 (online) 10.1002/advs.202003838 https://hdl.handle.net/20.500.14352/7891 https://doi.org/10.1002/advs.202003838 https://onlinelibrary.wiley.com/doi/10.1002/advs.202003838 Luminescent nano‐thermometry is a fast‐developing technique with great potential for in vivo sensing, diagnosis, and therapy. Unfortunately, it presents serious limitations. The luminescence generated by nanothermometers, from which thermal readout is obtained, is strongly distorted by the attenuation induced by tissues. Such distortions lead to low signal levels and entangle absolute and reliable thermal monitoring of internal organs. Overcoming both limitations requires the use of high‐brightness luminescent nanothermometers and adopting more complex approaches for temperature estimation. In this work, it is demonstrated how superbright Ag2S nanothermometers can provide in vivo, reliable, and absolute thermal reading of the liver during laser‐induced hyperthermia. For that, a new procedure is designed in which thermal readout is obtained from the combination of in vivo transient thermometry measurements and in silico simulations. The synergy between in vivo and in silico measurements has made it possible to assess relevant numbers such as the efficiency of hyperthermia processes, the total heat energy deposited in the liver, and the relative contribution of Ag2S nanoparticles to liver heating. This work provides a new way for absolute thermal sensing of internal organs with potential application not only to hyperthermia processes but also to advanced diagnosis and therapy. daniel.jaque@uam.es eng Atribución 3.0 España Reaching Deeper: Absolute In Vivo Thermal Reading of Liver by Combining Superbright Ag2S Nanothermometers and In Silico Simulations journal article URL https://docta.ucm.es/bitstreams/7f71f32f-261b-4fa3-aecb-518bbc265f93/download File MD5 8040fa22fcb006dbc87022d4ac789cf8 2582243 application/pdf Melle_ 2021_advs.202003838.pdf URL https://docta.ucm.es/bitstreams/8c2b05fe-acfd-44af-970e-b270d4c4f35a/download File MD5 f22a798de02594a170c77913a0938633 54838 text/plain Melle_ 2021_advs.202003838.pdf.txt