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oai:docta.ucm.es:20.500.14352/81042024-09-27T15:36:42Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Guzmán Solís, Eduardo author Santini, Eva author Ferrari, Michele author Liggieri, Libero author Ravera, Francesca 2023-06-17T09:04:29Z 2023-06-17T09:04:29Z 2020-05-10 2079-6412 10.3390/coatings10050469 https://hdl.handle.net/20.500.14352/8104 https://doi.org/10.3390/coatings10050469 https://www.mdpi.com/2079-6412/10/5/469 Lipid layers are considered among the first protective barriers of the human body against pollutants, e.g., skin, lung surfactant, or tear film. This makes it necessary to explore the physico-chemical bases underlying the interaction of pollutants and lipid layers. This work evaluates using a pool of surface-sensitive techniques, the impact of carbon black and fumed silica particles on the behavior of Langmuir monolayers of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC). The results show that the incorporation of particles into the lipid monolayers affects the surface pressure–area isotherm of the DPPC, modifying both the phase behavior and the collapse conditions. This is explained considering that particles occupy a part of the area available for lipid organization, which affects the lateral organization of the lipid molecules, and consequently the cohesion interactions within the monolayer. Furthermore, particles incorporation worsens the mechanical performance of lipid layers, which may impact negatively in different processes presenting biological relevance. The modification induced by the particles has been found to be dependent on their specific chemical nature. This work tries to shed light on some of the most fundamental physico-chemical bases governing the interaction of pollutants with lipid layers, which plays an essential role on the design of strategies for preventing the potential health hazards associated with pollution. eng Atribución 3.0 España Interaction of Particles with Langmuir Monolayers of 1,2-Dipalmitoyl-Sn-Glycero-3-Phosphocholine: A Matter of Chemistry? journal article URL https://docta.ucm.es/bitstreams/7fefeb95-c6f8-469b-b8ec-a535b147f357/download File MD5 5972b87814ecd2ac74377054520d411c 4870312 application/pdf coatings-10-00469-v2.pdf