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00925njm 22002777a 4500 dc Cores Esperón, Ángel author Piquero Martí, Marta author Villacampa Sanz, Mercedes author León Martínez, Rafael author Menéndez Ramos, José Carlos author 2020-06-14 NRF2 acts by controlling gene expression, being the master regulator of the Phase II antioxidant response, and also being key to the control of neuroinflammation. NRF2 activity is regulated at several levels, including protein degradation by the proteasome, transcription, and post-transcription. The purpose of this review is to offer a concise and critical overview of the main mechanisms of NRF2 regulation and their actual or potential use as targets for the treatment of neurodegenerative diseases. 2218-273X 10.3390/biom10060904 https://hdl.handle.net/20.500.14352/8385 https://doi.org/10.3390/biom10060904 https://www.mdpi.com/2218-273X/10/6/904 NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases