2026-06-29T01:32:37Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/83852024-04-23T13:59:06Zcom_20.500.14352_14col_20.500.14352_15
NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases
Cores Esperón, Ángel
Piquero Martí, Marta
Villacampa Sanz, Mercedes
León Martínez, Rafael
Menéndez Ramos, José Carlos
NRF2–ARE pathway
neurodegenerative diseases
oxidative stress
KEAP1
NRF2 regulation
Neurociencias (Farmacia)
2490 Neurociencias
NRF2 acts by controlling gene expression, being the master regulator of the Phase II antioxidant response, and also being key to the control of neuroinflammation. NRF2 activity is regulated at several levels, including protein degradation by the proteasome, transcription, and post-transcription. The purpose of this review is to offer a concise and critical overview of the main mechanisms of NRF2 regulation and their actual or potential use as targets for the treatment of neurodegenerative diseases.
Ministerio de Ciencia e Innovación (MICINN)
Ministerio de Economía y Competitividad (MINECO)
Comunidad de Madrid
Instituto de Salud Carlos III (ISCIII)/FEDER
Instituto de Salud Carlos III
Depto. de Química en Ciencias Farmacéuticas
Fac. de Farmacia
TRUE
pub
2023-06-17T09:12:10Z
2023-06-17T09:12:10Z
2020-06-14
journal article
https://hdl.handle.net/20.500.14352/8385
2218-273X
10.3390/biom10060904
eng
(RTI2018-097662-B-I00; FPU15/03608)
BES-2016-076410P
NRF24AD-CM (B2017/BMD-3827); ELA-MADRID-CM (B2017/BMD-3813)
Miguel Servet II Program (CP16/00014)
(grant PI17/01700)
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
open access
application/pdf
MDPI