2026-06-27T23:16:37Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/86682023-08-27T02:27:27Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense
author
Carballeda-Sangiao, Noelia
author
Chamorro Francisco, Susana
author
Pascual-Teresa, Sonia de
2023-06-17T09:22:11Z
2023-06-17T09:22:11Z
2021-05-27
1420-3049, ESSN: 1420-3049
10.3390/molecules26113210
https://hdl.handle.net/20.500.14352/8668
https://doi.org/10.3390/molecules26113210
https://www.mdpi.com/1420-3049/26/11/3210
Recommendations towards increased consumption of fresh fruit and vegetables are well supported by epidemiological and clinical trials. However, in some specific cases, it is difficult to follow these recommendations and the use of nutraceuticals or, in the present work, a freezedried fruits mixture can be recommended in order to afford the optimal consumption of dietary polyphenols naturally present in fruits and vegetables. In this work we have carefully characterized a red-berry mixture in terms of polyphenol composition, encountering mainly anthocyanins, which account for a total of 2.8 mg/g as cyanidin-3-glucoside equivalents. Additionally, we have assayed the red-berry blend in a cell model of neurological damage by differentiating the cells and measuring the effect of red-berry polyphenols on cell viability and redox state by flow cytometry. The berry-fruit extract showed an inhibitory effect on differentiated SH-SY5Y ROS formation at a concentration as low as 250 µg/mL (33% inhibition). The results show the potential of this berry-fruit blend for its nutraceutical use in the prevention of the neurodegeneration associated with age or environmental agents.
eng
Atribución 3.0 España
A Red-Berry mixture as a Nutraceutical: detailed composition
and neuronal protective effect
journal article
URL
https://docta.ucm.es/bitstreams/b0a441cf-7042-4b59-8091-a65f84747fc5/download
File
MD5
c838cedd131d0326fe055a7f33db62a2
2398122
application/pdf
Carballeda-Sangiao, N. et al.2021A Red-Berry Mixture as a Nutraceutical....pdf