2026-06-28T09:44:38Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/890212024-09-11T00:01:42Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense
author
Palazuelos Diego, Javier
author
Klingener, Michael
author
Raines, Elaine
author
Crawford, Howard
author
Aguirre, Adan
2023-11-28T15:28:46Z
2023-11-28T15:28:46Z
2015
Palazuelos, Javier, et al. «Oligodendrocyte Regeneration and CNS Remyelination Require TACE/ADAM17». The Journal of Neuroscience, vol. 35, n.o 35, septiembre de 2015, pp. 12241-47. https://doi.org/10.1523/JNEUROSCI.3937-14.2015.
0270-6474
10.1523/jneurosci.3937-14.2015
https://hdl.handle.net/20.500.14352/89021
1529-2401
https://doi.org/10.1523/JNEUROSCI.3937-14.2015
The identification of the molecular network that supports oligodendrocyte (OL) regeneration under demyelinating conditions has been a primary goal for regenerative medicine in demyelinating disorders. We recently described an essential function for TACE/ADAM17 in regulating oligodendrogenesis during postnatal myelination, but it is unknown whether this protein also plays a role in OL regeneration and remyelination under demyelinating conditions. By using genetic mouse models to achieve selective gain- or loss-of-function of TACE or EGFR in OL lineage cells in vivo, we found that TACE is critical for EGFR activation in OLs following demyelination, and therefore, for sustaining OL regeneration and CNS remyelination. TACE deficiency in oligodendrocyte progenitor cells following demyelination disturbs OL lineage cell expansion and survival, leading to a delay in the remyelination process. EGFR overexpression in TACE deficient OLs in vivo restores OL development and postnatal CNS myelination, but also OL regeneration and CNS remyelination following demyelination. Our study reveals an essential function of TACE in supporting OL regeneration and CNS remyelination that may contribute to the design of new strategies for therapeutic intervention in demyelinating disorders by promoting oligodendrocyte regeneration and myelin repair.
eng
Oligodendrocyte Regeneration and CNS Remyelination Require TACE/ADAM17
journal article
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