2026-06-27T15:19:54Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/910712024-01-03T02:53:57Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author París Ogayar, Marina author Méndez González, Diego author Zabala Gutiérrez, Irene author Artiga , Alvaro author Rubio Retama, Benito Jorge author Gómez Calderón, Óscar author Melle Hernández, Sonia author Alda Serrano, Javier author Espinosa, Ana author Jaque, Daniel author Marín Viadel, Ricardo 2023-12-04T17:16:16Z 2023-12-04T17:16:16Z 2023-10-19 París Ogáyar M, Mendez-Gonzalez D, Zabala Gutierrez I, Artiga Á, Rubio-Retama J, Calderón OG, Melle S, Serrano A, Espinosa A, Jaque D, Marin R. Ion-induced bias in Ag2S luminescent nanothermometers. Nanoscale. 2023 Nov 16;15(44):17956-17962. doi: 10.1039/d3nr03728b. PMID: 37905397. 2040-3364 10.1039/D3NR03728B https://hdl.handle.net/20.500.14352/91071 2040-3372 https://doi.org/10.1039/D3NR03728B Luminescence nanothermometry allows measuring temperature remotely and in a minimally invasive way by using the luminescence signal provided by nanosized materials. This technology has allowed, for example, the determination of intracellular temperature and in vivo monitoring of thermal processes in animal models. However, in the biomedical context, this sensing technology is crippled by the presence of bias (cross-sensitivity) that reduces the reliability of the thermal readout. Bias occurs when the impact of environmental conditions different from temperature also modifies the luminescence of the nanothermometers. Several sources that cause loss of reliability have been identified, mostly related to spectral distortions due to interaction between photons and biological tissues. In this work, we unveil an unexpected source of bias induced by metal ions. Specifically, we demonstrate that the reliability of Ag2S nanothermometers is compromised during the monitoring of photothermal processes produced by iron oxide nanoparticles. The observed bias occurs due to the heat-induced release of iron ions, which interact with the surface of the Ag2S nanothermometers, enhancing their emission. The results herein reported raise a warning to the community working on luminescence nanothermometry, since they reveal that the possible sources of bias in complex biological environments, rich in molecules and ions, are more numerous than previously expected. eng Attribution 4.0 International Ion-induced bias in Ag2S luminescent nanothermometers journal article 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