2026-06-08T04:03:06Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/911922024-07-23T23:46:56Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Muñoz Úbeda, Mónica author Carniato, Fabio author Catanzaro, Valeria author Padovan, Sergio author Grange, Cristina author Porta, Stefano author Carrera, Carla author Tei, Lorenzo author Digilio, Giuseppe author 2016 The redox microenvironment within a cell graft can be considered as an indicator to assess whether the graft is metabolically active or hypoxic. We present a redox-responsive MRI probe based on porous silica microparticles whose surface has been decorated with a Gdchelate through a disulphide bridge. Such microparticles are designed to be interspersed with therapeutic cells within a biocompatible hydrogel. The onset of reducing conditions within the hydrogel is paralleled by an increased clearance of Gd, that can be detected by MRI. M. Muñoz Úbeda, F. Carniato, V. Catanzaro, S. Padovan, C. Grange, S. Porta, C. Carrera, L. Tei, G. Digilio, Chem. Eur. J. 2016, 22, 7716. 0947-6539 10.1002/chem.201600962 https://hdl.handle.net/20.500.14352/91192 https://doi.org/10.1002/chem.201600962 Gadolinium-decorated silica microspheres as redox-responsive MRI probes for applications in cell therapy follow-up