2026-06-07T21:21:25Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/911922024-07-23T23:46:56Zcom_20.500.14352_14col_20.500.14352_15

Muñoz Úbeda, Mónica Carniato, Fabio Catanzaro, Valeria Padovan, Sergio Grange, Cristina Porta, Stefano Carrera, Carla Tei, Lorenzo Digilio, Giuseppe 2023-12-12T11:15:36Z 2023-12-12T11:15:36Z 2016 M. Muñoz Úbeda, F. Carniato, V. Catanzaro, S. Padovan, C. Grange, S. Porta, C. Carrera, L. Tei, G. Digilio, Chem. Eur. J. 2016, 22, 7716. 0947-6539 10.1002/chem.201600962 https://hdl.handle.net/20.500.14352/91192 https://doi.org/10.1002/chem.201600962 The redox microenvironment within a cell graft can be considered as an indicator to assess whether the graft is metabolically active or hypoxic. We present a redox-responsive MRI probe based on porous silica microparticles whose surface has been decorated with a Gdchelate through a disulphide bridge. Such microparticles are designed to be interspersed with therapeutic cells within a biocompatible hydrogel. The onset of reducing conditions within the hydrogel is paralleled by an increased clearance of Gd, that can be detected by MRI. eng http://creativecommons.org/licenses/by-nc-nd/4.0/ restricted access Attribution-NonCommercial-NoDerivatives 4.0 International Gadolinium-decorated silica microspheres as redox-responsive MRI probes for applications in cell therapy follow-up journal article