2026-06-08T01:18:40Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/911922024-07-23T23:46:56Zcom_20.500.14352_14col_20.500.14352_15
Gadolinium-decorated silica microspheres as redox-responsive MRI probes for applications in cell therapy follow-up
Muñoz Úbeda, Mónica
Carniato, Fabio
Catanzaro, Valeria
Padovan, Sergio
Grange, Cristina
Porta, Stefano
Carrera, Carla
Tei, Lorenzo
Digilio, Giuseppe
544
Química física (Química)
2307 Química Física
The redox microenvironment within a cell graft can be considered as an indicator to assess whether the graft is metabolically active or hypoxic. We present a redox-responsive MRI probe based on porous silica microparticles whose surface has been decorated with a Gdchelate through a disulphide bridge. Such microparticles are designed to be interspersed with therapeutic cells within a biocompatible hydrogel. The onset of reducing conditions within the hydrogel is paralleled by an increased clearance of Gd, that can be detected by MRI.
Ministry of Foreign Affairs and Cooperation (Italy)
Ministry of Education (Italy)
Depto. de Química Física
Fac. de Ciencias Químicas
TRUE
pub
2023-12-12T11:15:36Z
2023-12-12T11:15:36Z
2016
journal article
VoR
https://hdl.handle.net/20.500.14352/91192
0947-6539
10.1002/chem.201600962
eng
M. Muñoz Úbeda, F. Carniato, V. Catanzaro, S. Padovan, C. Grange, S. Porta, C. Carrera, L. Tei, G. Digilio, Chem. Eur. J. 2016, 22, 7716.
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
restricted access
application/pdf
Wiley