2026-06-08T02:43:28Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/911922024-07-23T23:46:56Zcom_20.500.14352_14col_20.500.14352_15
Gadolinium-decorated silica microspheres as redox-responsive MRI probes for applications in cell therapy follow-up
Muñoz Úbeda, Mónica
Carniato, Fabio
Catanzaro, Valeria
Padovan, Sergio
Grange, Cristina
Porta, Stefano
Carrera, Carla
Tei, Lorenzo
Digilio, Giuseppe
The redox microenvironment within a cell graft can be considered as an indicator to assess whether the graft is metabolically active or hypoxic. We present a redox-responsive MRI probe based on porous silica microparticles whose surface has been decorated with a Gdchelate through a disulphide bridge. Such microparticles are designed to be interspersed with therapeutic cells within a biocompatible hydrogel. The onset of reducing conditions within the hydrogel is paralleled by an increased clearance of Gd, that can be detected by MRI.
2023-12-12T11:15:36Z
2023-12-12T11:15:36Z
2016
journal article
M. Muñoz Úbeda, F. Carniato, V. Catanzaro, S. Padovan, C. Grange, S. Porta, C. Carrera, L. Tei, G. Digilio, Chem. Eur. J. 2016, 22, 7716.
0947-6539
10.1002/chem.201600962
https://hdl.handle.net/20.500.14352/91192
https://doi.org/10.1002/chem.201600962
eng
http://creativecommons.org/licenses/by-nc-nd/4.0/
restricted access
Attribution-NonCommercial-NoDerivatives 4.0 International
Wiley