2026-08-16T07:56:34Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/916932025-03-18T13:01:18Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Galve Roperh, Ismael author Aguado Sánchez, Tania author Palazuelos Diego, Javier author Guzmán Pastor, Manuel 2023-12-21T11:36:49Z 2023-12-21T11:36:49Z 2008 Galve-Roperh, Ismael, Aguado, Tania, Palazuelos, Javier and Guzman, Manuel. Mechanisms of Control of Neuron Survival by the Endocannabinoid System. Curr Pharm Des . 2008;14(23):2279-88 1381-6128 10.2174/138161208785740117 https://hdl.handle.net/20.500.14352/91693 1873-4286 https://doi.org/10.2174/138161208785740117 Endocannabinoids act as retrograde messengers that, by inhibiting neurotransmitter release via presynaptic CB1 cannabinoid receptors, regulate the functionality of many synapses. In addition, the endocannabinoid system participates in the control of neuron survival. Thus, CB1 receptor activation has been shown to protect neurons from acute brain injury as well as in neuroinflammatory conditions and neurodegenerative diseases. Nonetheless, some studies have reported that cannabinoids can also exert neurotoxic actions. Cannabinoid neuroprotective activity relies on the inhibition of glutamatergic neurotransmission and on other various mechanisms, and is supported by the observation that the brain overproduces endocannabinoids upon damage. Coupling of neuronal CB1 receptors to cell survival routes such as the phosphatidylinositol 3-kinase/Akt and extracellular signal-regulated kinase pathways may contribute to cannabinoid neuroprotective action. These pro-survival signals occur, at least in part, by the cross-talk between CB1 receptors and growth factor tyrosine kinase receptors. Besides promoting neuroprotection, a role for the endocannabinoid system in the control of neurogenesis from neural progenitors has been put forward. In addition, activation of CB2 cannabinoid receptors on glial cells may also participate in neuroprotection by limiting the extent of neuroinflammation. Altogether, these findings support that endocannabinoids constitute a new family of lipid mediators that act as instructive signals in the control of neuron survival. eng Mechanisms of Control of Neuron Survival by the Endocannabinoid System journal article 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URL https://docta.ucm.es/bitstreams/a1cb7756-d61d-4f9d-b8df-8ab7ee72f877/download File MD5 d5ad6524f51e93ae4938407981eab638 2461953 application/pdf Mechanisms_of_Control.pdf URL https://docta.ucm.es/bitstreams/db47cecc-eafe-451d-bc40-980a8dae51a8/download File MD5 96adb972ca961f2629130ce0e36489ec 68710 text/plain Galve-Roperth, I. 2008. Mechanisms of Control of Neuron Survival....pdf.txt URL https://docta.ucm.es/bitstreams/70f953ea-460b-4203-8a2c-91b874104dea/download File MD5 96adb972ca961f2629130ce0e36489ec 68710 text/plain Mechanisms_of_Control.pdf.txt