2026-06-27T15:22:34Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/921522025-08-06T17:22:34Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Almendro Vedia, Víctor Galileo author Monroy Muñoz, Francisco author Cao García, Francisco Javier author 2013 During symmetric division cells undergo large constriction deformations at a stable midcell site. Using a variational approach, we investigate the mechanical route for symmetric constriction by computing the bending energy of deformed vesicles with rotational symmetry. Forces required for constriction are explicitly computed at constant area and constant volume, and their values are found to be determined by cell size and bending modulus. For cell-sized vesicles, considering typical bending modulus of k = 10kBT, we calculate constriction forces in the range 0.1 - 1pN. The instability of symmetrical constriction is shown and quantified with a characteristic coefficient of the order of - 50kBT, thus evidencing that cells need a robust mechanism to stabilize constriction at midcell. Almendro-Vedia, V.G., Monroy, F., Cao, F.J.: Mechanics of Constriction during Cell Division: A Variational Approach. PLOS ONE. 8, e69750 (2013). https://doi.org/10.1371/journal.pone.0069750 1932-6203 10.1371/journal.pone.0069750 https://hdl.handle.net/20.500.14352/92152 http://dx.doi.org/10.1371/journal.pone.0069750 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0069750 Mechanics of Constriction during Cell Division: A Variational Approach