2026-06-27T23:16:46Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/922512025-03-31T09:01:27Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Mo, Xiaomei author Li, Huacheng author Tang, Pan author Hao, Yaya author Dong, Bingqian author Marazuela Lamata, María Dolores author Gómez Gómez, María Milagros author Zhu, Xianfeng author Li, Qian author Lora Maroto, Beatriz author Jiang, Shuoxing author Fan, Chunhai author Lan, Xiang author 2023 Study of the conformational and mechanical behaviors of biomolecular assemblies is vital to the rational design and realization of artificial molecular architectures with biologically relevant functionality. Here, we revealed DNA-modulated and mechanoresponsive excitonic couplings between organic chromophores and verified strong correlations between the excitonic chiroptical responses and the conformational and mechanical states of DNA self-assemblies irrespective of fluorescence background interference. Besides, the excitonic chiroptical effect allowed sensitive monitoring of DNA self-assembled nanostructures due to small molecule bindings or DNA strand displacement reactions. Moreover, we developed a new chiroptical reporter, a DNAtemplated dimer of an achiral cyanine5 and an intrinsically chiral BODIPY, that exhibited unique multiple-split spectral line shape of exciton-coupled circular dichroism, largely separated response wavelengths, and enhanced anisotropy dissymmetry factor (g-factor). These results shed light on a promising chiroptical spectroscopic tool for studying biomolecular recognition and binding, conformation dynamics, and soft mechanics in general. DNA-Modulated and Mechanoresponsive Excitonic Couplings Reveal Chiroptical Correlation of Conformation, Tension, and Dynamics of DNA Self-Assembly Xiaomei Mo, Huacheng Li, Pan Tang, Yaya Hao, Bingqian Dong, M. Dolores Marazuela, M. Milagros Gomez-Gomez, Xianfeng Zhu, Qian Li, Beatriz L. Maroto, Shuoxing Jiang, Chunhai Fan, and Xiang Lan Nano Letters 2023 23 (24), 11734-11741 DOI: 10.1021/acs.nanolett.3c03652 1530-6984 10.1021/acs.nanolett.3c03652 https://hdl.handle.net/20.500.14352/92251 1530-6992 https://doi.org/10.1021/acs.nanolett.3c03652 DNA-Modulated and Mechanoresponsive Excitonic Couplings Reveal Chiroptical Correlation of Conformation, Tension, and Dynamics of DNA Self-Assembly