2026-06-26T20:29:46Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/922512025-03-31T09:01:27Zcom_20.500.14352_14col_20.500.14352_15

Mo, Xiaomei Li, Huacheng Tang, Pan Hao, Yaya Dong, Bingqian Marazuela Lamata, María Dolores Gómez Gómez, María Milagros Zhu, Xianfeng Li, Qian Lora Maroto, Beatriz Jiang, Shuoxing Fan, Chunhai Lan, Xiang 2024-01-10T12:55:35Z 2024-01-10T12:55:35Z 2023 DNA-Modulated and Mechanoresponsive Excitonic Couplings Reveal Chiroptical Correlation of Conformation, Tension, and Dynamics of DNA Self-Assembly Xiaomei Mo, Huacheng Li, Pan Tang, Yaya Hao, Bingqian Dong, M. Dolores Marazuela, M. Milagros Gomez-Gomez, Xianfeng Zhu, Qian Li, Beatriz L. Maroto, Shuoxing Jiang, Chunhai Fan, and Xiang Lan Nano Letters 2023 23 (24), 11734-11741 DOI: 10.1021/acs.nanolett.3c03652 1530-6984 10.1021/acs.nanolett.3c03652 https://hdl.handle.net/20.500.14352/92251 1530-6992 https://doi.org/10.1021/acs.nanolett.3c03652 Study of the conformational and mechanical behaviors of biomolecular assemblies is vital to the rational design and realization of artificial molecular architectures with biologically relevant functionality. Here, we revealed DNA-modulated and mechanoresponsive excitonic couplings between organic chromophores and verified strong correlations between the excitonic chiroptical responses and the conformational and mechanical states of DNA self-assemblies irrespective of fluorescence background interference. Besides, the excitonic chiroptical effect allowed sensitive monitoring of DNA self-assembled nanostructures due to small molecule bindings or DNA strand displacement reactions. Moreover, we developed a new chiroptical reporter, a DNAtemplated dimer of an achiral cyanine5 and an intrinsically chiral BODIPY, that exhibited unique multiple-split spectral line shape of exciton-coupled circular dichroism, largely separated response wavelengths, and enhanced anisotropy dissymmetry factor (g-factor). These results shed light on a promising chiroptical spectroscopic tool for studying biomolecular recognition and binding, conformation dynamics, and soft mechanics in general. eng open access DNA-Modulated and Mechanoresponsive Excitonic Couplings Reveal Chiroptical Correlation of Conformation, Tension, and Dynamics of DNA Self-Assembly journal article