2026-07-18T13:58:35Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/924142024-07-31T00:05:06Zcom_20.500.14352_14col_20.500.14352_15
Resistance to the “last resort” antibiotic colistin: a single-zinc mechanism for phosphointermediate formation in MCR enzymes
Lythell, Emily
Suardíaz Delrío, Reynier
Hinchliffe, Philip
Hanpaibool, Chonnikan
Visitsatthawong, Surawit
Oliveira, Sofia
Lang, Eric
Surawatanawong, Panida
Lee, Vannajan Sanghiran
Rungrotmongkol, Thanyada
Fey, Natalie
Spencer, James
Mulholland, Adrian
MCR (mobile colistin resistance) enzymes catalyse phosphoethanolamine (PEA) addition to bacterial lipid A, threatening the “last-resort” antibiotic colistin. Molecular dynamics and density functional theory simulations indicate that monozinc MCR supports PEA transfer to the Thr285 acceptor, positioning MCR as a mono- rather than multinuclear member of the alkaline phosphatase superfamily.
2024-01-11T07:50:40Z
2024-01-11T07:50:40Z
2024-01-11T07:50:40Z
2020
journal article
https://hdl.handle.net/20.500.14352/92414
1359-7345
10.1039/d0cc02520h
1364-548X
eng
EP/M013219/1
EP/M022609/1
EP/M027546/1
RSA6280041
BB/J014400/1
BB/L01386X/1
BB/M012107/1
MR/P007295/1
GPF062B-2018
R19-3409
Lythell, Emily, et al. «Resistance to the “Last Resort” Antibiotic Colistin: A Single-Zinc Mechanism for Phosphointermediate Formation in MCR Enzymes». Chemical Communications, vol. 56, n.o 50, 2020, pp. 6874-77. https://doi.org/10.1039/D0CC02520H.
http://creativecommons.org/licenses/by-nc-nd/4.0/
restricted access
Attribution-NonCommercial-NoDerivatives 4.0 International
Royal Society of Chemistry