2026-06-07T19:16:36Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/924332024-01-12T02:22:02Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Jemni Damer , Nahla author Guedan Duran , Atocha author Fuentes Andion , María author Serrano Bengoechea , Nora author Alfageme Lopez, Nuria author Armada Maresca, Felix author Guinea , Gustavo V. author Perez Rigueiro , José author Rojo Vázquez, Francisco Antonio author Gonzalez Nieto, Daniel author Kaplan, David L. author Panetsos Petrova, Fivos author 2020-12-10 Age-related Macular Degeneration (AMD) is an up-to-date untreatable chronic neurodegenerative eye disease of multifactorial origin, and the main causes of blindness in over 65 y.o. people. It is characterized by a slow progression and the presence of a multitude of factors, highlighting those related to diet, genetic heritage and environmental conditions, present throughout each of the stages of the illness. Current therapeutic approaches, mainly consisting on intraocular drug delivery, are only used for symptoms relief and/or to decelerate the progression of the disease. Furthermore, they are overly simplistic and ignore the complexity of the disease and the enormous differences in the symptomatology between patients. Due to the wide impact of the AMD and the up-to-date absence of clinical solutions, Due to the wide impact of the AMD and the up-to-date absence of clinical solutions, different treatment options have to be considered. Cell therapy is a very promising alternative to drug-based approaches for AMD treatment. Cells delivered to the affected tissue as a suspension have shown poor retention and low survival rate. A solution to these inconveniences has been the encapsulation of these cells on biomaterials, which contrive to their protection, gives them support, and favor their retention of the desired area. We offer a two-papers critical review of the available and under development AMD therapeutic approaches, from a biomaterials and biotechnological point of view. We highlight benefits and limitations and we forecast forthcoming alternatives based on novel biomaterials and biotechnology methods. In this second part we review the preclinical and clinical cell-replacement approaches aiming at the development of efficient AMD-therapies, the employed cell types, as well as the cell-encapsulation and cell-implant systems. We discuss their advantages and disadvantages and how they could improve the survival and integration of the implanted cells. Jemni-Damer N, Guedan-Duran A, Fuentes-Andion M, Serrano-Bengoechea N, Alfageme-Lopez N, Armada-Maresca F, Guinea GV, Perez-Rigueiro J, Rojo F, Gonzalez-Nieto D, Kaplan DL and Panetsos F (2020) Biotechnology and Biomaterial-Based Therapeutic Strategies for Age-Related Macular Degeneration. Part II: Cell and Tissue Engineering Therapies. Front. Bioeng. Biotechnol. 8:588014. 10.3389/fbioe.2020.588014 https://hdl.handle.net/20.500.14352/92433 2296-4185 https://doi.org/10.3389/fbioe.2020.588014 Biotechnology and Biomaterial-Based Therapeutic Strategies for Age-Related Macular Degeneration. Part II: Cell and Tissue Engineering Therapies