2026-06-08T03:45:50Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/926182025-03-10T13:33:21Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense
author
Ochoa-Grullón, Juliana
author
Benavente Cuesta, Celina
author
Pérez López, César
author
Peña Cortijo, Ascensión
author
Mateos-Aparicio Morales, Gregoria
author
Fernández Arquero, Miguel
author
Recio Hoyas, María José
author
Sánchez-Ramón, Silvia
2024-01-11T17:02:55Z
2024-01-11T17:02:55Z
2020
Ochoa-Grullón J, Benavente Cuesta C, Pérez López C, Peña Cortijo A, Rodríguez de la Peña A, Álvarez Carmona A, Mateo Morales M, Llano-Hernández K, Williams LJ, Rodríguez de Frías E, Guevara-Hoyer K, Cordero Torres G, Orte C, Fernández-Arquero M, Fernández-Paredes L, Serrano-García I, Recio MJ, Pérez de Diego R, Martínez R, Sánchez-Ramón S. Clin Immunol. 2020 Jan;210:108307.
1521-6616
10.1016/j.clim.2019.108307
https://hdl.handle.net/20.500.14352/92618
https://doi.org/10.1016/j.clim.2019.108307
An increasing healthcare challenge in the management of haematological malignancy (HM) is secondary immunodeficiency. From January 2019, the EMA included the evaluation of specific antibody (Ab) responses to better select patients for immunoglobulin replacement therapy (IgRT). We evaluated Ab responses to pneumococcal and Salmonella typhi pure polysaccharide immunization in a cohort of 42 HM patients and 24 healthy-controls. Pre-post specific Ab concentrations were measured by ELISA at 4 weeks. Globally, significantly lower Typhim Vi (TV) seroprevalence (9%) compared to 23-valent pneumococcal polysaccharide vaccine (PPV) (76%) (p <0.001) was observed. TV non responders (88%) were higher than PPV non responders (62%) (p <0.0001) and correlated better to infectious history. By ROC analysis, pre-post 5-fold TV increase was the best cut-off to discriminate HM with recurrent infections and controls (sensitivity 91%, specificity 100%). Despite the small sample cohort, our results suggest that specific anti-S typhi Ab response is a useful complementary assay in the diagnosis and management decision of SID to HM.
eng
Attribution-NonCommercial-NoDerivatives 4.0 International
Evaluation of Polysaccharide Typhim Vi Antibody Response as a predictor of Humoral Immunodeficiency in Haematological Malignancies
journal article
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ClinImmunol_20.pdf.txt