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oai:docta.ucm.es:20.500.14352/926972025-01-28T01:03:38Zcom_20.500.14352_14col_20.500.14352_15

Zuluaga, Susana Gutiérrez Uzquiza, Álvaro Bragado, Paloma Alvarez-Barrientos, Alberto Benito De Las Heras, Manuel R. Nebreda, Angel R Porras Gallo, María Almudena 2024-01-12T09:47:22Z 2024-01-12T09:47:22Z 2007 Fraguas-Sánchez AI, Fernández-Carballido A, Martin-Sabroso C, Torres-Suárez AI. Stability characteristics of cannabidiol for the design of pharmacological, biochemical and pharmaceutical studies. Journal of Chromatography B 2020;1150:122188. https://doi.org/10.1016/j.jchromb.2020.122188. 0014-5793 10.1016/j.febslet.2007.06.078 https://hdl.handle.net/20.500.14352/92697 1873-3468 https://doi.org/10.1016/j.febslet.2007.06.078 https://febs.onlinelibrary.wiley.com/doi/10.1016/j.febslet.2007.06.078 The small GTP-ase Rac-1 can trigger p38 MAPK activation and, in turn, p38alpha can regulate signalling pathways that potentially impinge on Rac-1 activity. We have investigated the cross-talk between p38alpha and Rac-1 and found that p38alpha regulates the association between Rac-1 and caveolin-1 in serum-deprived cardiomyocytes. This interaction depends on cell attachment and correlates with higher levels of active Rac-1. Actin organization might regulate the formation of Rac-1-caveolin-1 complexes. In contrast, the Rac-1-caveolin-1 interaction is almost undetectable in the presence of serum, where Rac-1 activity is negatively regulated by p38alpha. Our results indicate that p38alpha can differentially contribute to Rac-1 activation depending on the presence of serum. eng http://creativecommons.org/licenses/by-nc-nd/4.0/ restricted access Attribution-NonCommercial-NoDerivatives 4.0 International p38alpha MAPK can positively or negatively regulate Rac-1 activity depending on the presence of serum journal article