2026-07-30T02:45:21Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/928462025-03-27T00:51:46Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Mirza-Aghazadeh-Attari, Mohammad author Recio Hoyas, María José author Ghazizadeh Darband, Saber author Kaviani, Mojtaba author Safa, Amin author Mihanfar, Ainaz author Sadighparvar, Shirin author Karimian, Ansar author Alemi, Forough author Majidinia, Maryam author Yousefi, Bahman author 2021 Breast cancer is the most common and significant cancers in females regarding the loss of life quality. Similar to other cancers, one of the etiologic factors in breast cancer is DNA damage. A plethora of molecules are responsible for sensing DNA damage and mediating actions which lead to DNA repair, senescence, cell cycle arrest and if damage is unbearable to apoptosis. In each of these, aberrations leading to unrepaired damage was resulted in uncontrolled proliferation and cancer. Another cellular function is autophagy defined as a process eliminating of unnecessary proteins in stress cases involved in pathogenesis of cancer. Knowing their role in cancer, scholars have tried to develop strategies in order to target DDR and autophagy. Further, the interactions of DDR and autophagy plus their regulatory role on each other have been focused simultaneously. The present review study has aimed to illustrate the importance of DDR and autophagy in breast cancer according to the related studies and uncover the relation between DDR and autophagy and its significance in breast cancer therapy. Mirza-Aghazadeh-Attari M, Recio MJ, Darband SG, Kaviani M, Safa A, Mihanfar A, Sadighparvar S, Karimian A, Alemi F, Majidinia M, Yousefi B. DNA Repair (Amst). 2021 Feb;98:103032. 1568-7864 10.1016/j.dnarep.2020.103032 https://hdl.handle.net/20.500.14352/92846 https://doi.org/10.1016/j.dnarep.2020.103032 DNA damage response and breast cancer development: Possible therapeutic applications of ATR, ATM, PARP, BRCA1 inhibition