2026-06-27T23:58:42Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/930752025-03-18T14:59:02Zcom_20.500.14352_14col_20.500.14352_15

Proanthocyanidins: Impact on Gut Microbiota and Intestinal Action Mechanisms in the Prevention and Treatment of Metabolic Syndrome Redondo-Castillejo, Rocío Garcimartín Álvarez, Alba Hernández Martín, Marina López-Oliva Muñoz, María Elvira Bocanegra De Juana, Aranzazu Macho González, Adrián Bastida Codina, Sara Benedí González, Juana María Sánchez Muniz, Francisco José The metabolic syndrome (MS) is a cluster of risk factors, such as central obesity, hyperglycemia, dyslipidemia, and arterial hypertension, which increase the probability of causing premature mortality. The consumption of high-fat diets (HFD), normally referred to high-saturated fat diets, is a major driver of the rising incidence of MS. In fact, the altered interplay between HFD, microbiome, and the intestinal barrier is being considered as a possible origin of MS. Consumption of proanthocyanidins (PAs) has a beneficial effect against the metabolic disturbances in MS. However, there are no conclusive results in the literature about the efficacy of PAs in improving MS. This review allows a comprehensive validation of the diverse effects of the PAs on the intestinal dysfunction in HFD-induced MS, differentiating between preventive and therapeutic actions. Special emphasis is placed on the impact of PAs on the gut microbiota, providing a system to facilitate comparison between the studies. PAs can modulate the microbiome toward a healthy profile and strength barrier integrity. Nevertheless, to date, published clinical trials to verify preclinical findings are scarce. Finally, the preventive consumption of PAs in MS-associated dysbiosis and intestinal dysfunction induced by HFD seems more successful than the treatment strategy. 2024-01-15T12:16:11Z 2024-01-15T12:16:11Z 2024-01-15T12:16:11Z 2023-03-10 journal article https://hdl.handle.net/20.500.14352/93075 1661-6596 10.3390/ijms24065369 1422-0067 eng info:eu-repo/grantAgreement/PID2019-103872RB-I00 info:eu-repo/grantAgreement/AEI/10.13039/501100011033 Rocío Redondo-Castillejo, Alba Garcimartín, Marina Hernández-Martín, María Elvira López-Oliva, Aránzazu Bocanegra, Adrián Macho-González, Sara Bastida, Juana Benedí, Francisco J. Sánchez-Muniz. Proanthocyanidins: Impact on Gut Microbiota and Intestinal Action Mechanisms in the Prevention and Treatment of Metabolic Syndrome. International Journal of Molecular Sciences 2023, 24 (6) , 5369 https://creativecommons.org/licenses/by/4.0/ open access Attribution 4.0 International MDPI