2026-06-28T04:44:22Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/931722025-03-18T12:21:49Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author La Manna, Sara author Di Natale, Concetta author Panzetta, Valeria author Leone, Marilisa author Mercurio, Flavia author Cipollone, Irene author Monti, Maria author Netti, Paolo author Ferraro, Giarita author Terán More, Aaron author Sánchez Peláez, Ana Edilia author Herrero Domínguez, Santiago author Merlino, Antonello author Marasco, Daniela 2024-01-15T15:56:55Z 2024-01-15T15:56:55Z 2024 Sara La Manna, Concetta Di Natale, Valeria Panzetta, Marilisa Leone, Flavia A. Mercurio, Irene Cipollone, Maria Monti, Paolo A. Netti, Giarita Ferraro, Aarón Terán, Ana E. Sánchez-Peláez, Santiago Herrero, Antonello Merlino, and Daniela Marasco Inorganic Chemistry 2024 63 (1), 564-575 DOI: 10.1021/acs.inorgchem.3c03441 0020-1669 10.1021/acs.inorgchem.3c03441 https://hdl.handle.net/20.500.14352/93172 https://doi.org/10.1021/acs.inorgchem.3c03441 The physical and chemical properties of paddlewheel diruthenium compounds are highly dependent on the nature of the ligands surrounding the bimetallic core. Herein, we compare the ability of two diruthenium compounds, [Ru2Cl(D-p-FPhF)- (O2CCH3)3]·H2O (1) (D-p-FPhF− = N,N′-bis(4-fluorophenyl)- formamidinate) and K3[Ru2(O2CO)4]·3H2O (2), to act as inhibitors of amyloid aggregation of the Aβ1−42 peptide and its peculiar fragments, Aβ1−16 and Aβ21−40. A wide range of biophysical techniques has been used to determine the inhibition capacity against aggregation and the possible mechanism of action of these compounds (Thioflavin T fluorescence and autofluorescence assays, UV−vis absorption spectroscopy, circular dichroism, nuclear magnetic resonance, mass spectrometry, and electron scanning microscopy). Data show that the most effective inhibitory effect is shown for compound 1. This compound inhibits fiber formation and completely abolishes the cytotoxicity of Aβ1−42. The antiaggregatory capacity of this complex can be explained by a binding mechanism of the dimetallic units to the peptide chain along with π−π interactions between the formamidinate ligand and the aromatic side chains. The results suggest the potential use of paddlewheel diruthenium complexes as neurodrugs and confirm the importance of the steric and charge effects on the properties of diruthenium compounds eng Attribution-NonCommercial-NoDerivatives 4.0 International A Diruthenium Metallodrug as a Potent Inhibitor of Amyloid-β Aggregation: Synergism of Mechanisms of Action journal article 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