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Determination of phenolic compounds in residual brewing yeast using matrix solid-phase dispersion extraction assisted by titanium dioxide nanoparticles Gómez Mejía, Esther Rosales Conrado, Noelia León González, María Eugenia de Madrid Albarrán, María Yolanda 543 Polyphenols Residual brewing yeast cLC-DAD LC–MS/MS Matrix solid-phase dispersion Titanium dioxide nanoparticles Química analítica (Química) 2301 Química Analítica A simple and efficient low-cost matrix solid-phase dispersion (MSPD) extraction based on TiO2nanopar-ticles (NPs) and diatomaceous earth has been developed for the recovery of phenolic compounds fromresidual brewing yeast. Experimental conditions for MSPD extraction were optimized by an experimen-tal design approach. A screening factorial design plus replicates at the center point, followed by surfaceresponse analysis were used. The simultaneous identification and quantification of eleven main nat-ural polyphenols: caffeic, chlorogenic, p-coumaric, 3,4-dihydroxibenzoic, trans-ferulic and gallic acids,kaempferol, myricetin, naringin, quercetin and rutin, was possible by combining MSPD and capillaryliquid chromatography couple to a diode array detection system (cLC-DAD) and liquid chromatogra-phy couple to a triple quadrupole analyzer (LC–MS/MS). Moreover, residual brewing yeast extracts wereevaluated in terms of DPPH (1,1-diphenyl–2 picrylhydrazyl) free radical scavenging activity. Polyphenol-nanoparticle interaction was studied by UV–vis spectroscopy and electron transmission microscopy(TEM), pointing out a stable interplay that assists phenolic isolation. The extracted polyphenol quan-tities were within the 3.2-1,500 g g−1range, and the high antioxidant activity estimated suggested thatdeveloped MSPD is a successful, simple, efficient and rapid method for the extraction and recovery of bioactive phenolic compounds, which promotes the reuse and re-evaluation of brewing yeast agri-foodby-products. Comunidad de Madrid Ministerio de Economía y Competitividad (España) Universidad Complutense de Madrid European Commission Depto. de Química Analítica Fac. de Ciencias Químicas TRUE pub 2024-01-16T10:33:48Z 2024-01-16T10:33:48Z 2019 journal article VoR https://hdl.handle.net/20.500.14352/93305 0021-9673 10.1016/j.chroma.2019.05.009 eng 2018/BAA4393, AVANSECAL-II-CM CTQ 2017-83569-C2-1-R CT17/17-CT18/17 Gómez-Mejía E, Rosales-Conrado N, León-González ME, Madrid Y, Determination of phenolic compounds in residual brewing yeastusing matrix solid-phase dispersion extraction assisted by titaniumdioxide nanoparticles 2019, 1601:255-265 restricted access application/pdf Elsevier