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oai:docta.ucm.es:20.500.14352/934802024-07-11T00:06:35Zcom_20.500.14352_14col_20.500.14352_15

Cocrystallization of the anticancer drug 5-fluorouracil and coformers urea, thiourea or pyrazinamide using supercritical CO2 as an antisolvent (SAS) and as a solvent (CSS) Cuadra Mendoza, Isaac Alfonso Cabañas Poveda, Albertina Rodríguez Cheda, José Antonio Türk, MIchael Pando García-Pumarino, Concepción 547 615.01/.03 66 Carbon dioxide Pharmaceutical co-crystals Supercritical antisolvent Cocrystallization with supercritical solvent 5-fluorouracil Química física (Química) Farmacología (Farmacia) Materiales Ingeniería química 2307 Química Física 23 Química 3209 Farmacología 3303 Ingeniería y Tecnología Químicas Co-crystals of 5-fluorouracil (5-Fu) and the coformers urea, thiourea and pyrazinamide (PZA) were attempted for the first time through the supercritical antisolvent (SAS) and the cocrystallization with supercritical solvent (CSS) techniques. SAS operational conditions were temperature (313 K), pressure (7.0–15.0 MPa) and 5-Fu concentration in methanol (5 and 2.5 mg/mL). Coformer concentration was always in the desired stoichiometric ratio. Co-crystals were characterized using powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). Pure 5-Fu-urea cocrystals were obtained via SAS at 313 K and 8.0 MPa using a 5 mg/mL 5-Fu solution. All other SAS conditions studied led to 5-Fu homocrystal impurities. For comparison purposes 5-Fu, urea and thiourea were also processed by SAS. CSS produced a mixture of co-crystals and homocrystals only when supercritical CO2 was modified with methanol. Advantages and disadvantages of the two supercritical cocrystallization techniques are discussed. Ministerio de Economía y Competitividad (España) Universidad Complutense de Madrid Depto. de Química Física Fac. de Ciencias Químicas TRUE pub 2024-01-16T18:44:44Z 2024-01-16T18:44:44Z 2020 journal article VoR https://hdl.handle.net/20.500.14352/93480 0896-8446 10.1016/j.supflu.2020.104813 eng RTI2018-097230-B-I00 y UCM-Santander PR75/18-21583 Isaac A. Cuadra, Albertina Cabañas, José A.R. Cheda, Michael Türk, Concepción Pando, Cocrystallization of the anticancer drug 5-fluorouracil and coformers urea, thiourea or pyrazinamide using supercritical CO2 as an antisolvent (SAS) and as a solvent (CSS), The Journal of Supercritical Fluids, Volume 160, 2020, 104813 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ embargoed access application/pdf Elsevier