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oai:docta.ucm.es:20.500.14352/937302024-10-08T16:19:49Zcom_20.500.14352_14col_20.500.14352_15

De las Heras Molina, Ana Pesántez Pacheco, José Luis García Contreras, Consolación Vázquez Gómez, Marta López, Adrián Benítez, Rita Núñez, Yolanda Astiz, Susana Óvilo, Cristina Isabel Redondo, Beatriz González Bulnes, Antonio 2024-01-17T22:49:43Z 2024-01-17T22:49:43Z 2021-06 Heras-Molina, Ana, José Luis Pesántez-Pacheco, Consolación Garcia-Contreras, Marta Vázquez-Gómez, Adrián López, Rita Benítez, Yolanda Núñez, et al. «Maternal Supplementation with Polyphenols and Omega-3 Fatty Acids during Pregnancy: Prenatal Effects on Growth and Metabolism». Animals 11, n.o 6 (7 de junio de 2021): 1699. https://doi.org/10.3390/ani11061699. 10.3390/ani11061699 https://hdl.handle.net/20.500.14352/93730 https//doi.org/10.3390/ani11061699 https://www.mdpi.com/2076-2615/11/6/1699 Maternal supplementation with antioxidants and n-3 PUFAs may be a promising strategy to reduce the risk of intrauterine growth restriction and preterm delivery, which may diminish the appearance of low-birth-neonates. A previous studies showed beneficial outcomes of the combination of hydroxytyrosol and linoleic acid, but there is no data of its prenatal effects. The present study aimed to determine the possible prenatal implications of such maternal supplementation at prenatal stages in swine, a model of IUGR pregnancies. Results showed effects on litter size, with treated shows having larger litters and, therefore, smaller fetuses. However, the brain/head weight ratio showed a positive effect of the treatment in development, as well as in some other major organs like lungs, spleen, or kidneys. On the other hand, treated piglets showed better glycemic and lipidemic profiles, which could explain postnatal effects. However, further research on the implications of the treatment on litter size and prenatal and postnatal development must be done before practical recommendation can be given. eng http://creativecommons.org/licenses/by-nd/4.0/ open access Attribution-NoDerivatives 4.0 International Maternal Supplementation with Polyphenols and Omega-3 Fatty Acids during Pregnancy: Prenatal Effects on Growth and Metabolism journal article