2026-06-30T03:13:26Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/945192025-03-18T14:22:21Zcom_20.500.14352_14col_20.500.14352_15
Apoptosis, Toll-like, RIG-I-like and NOD-like Receptors Are Pathways Jointly Induced by Diverse Respiratory Bacterial and Viral Pathogens
Martínez, Isidoro
Oliveros, Juan
Cuesta, Isabel
Barrera, Jorge
Ausina, Vicente
Casals Carro, María Cristina
Lorenzo, Alba de
García, Ernesto
García-Fojeda García-Valdecasas, María Belén
Garmendia, Junkal
González-Nicolau, Mar
Lacoma, Alicia
Menéndez, Margarita
Moranta, David
Nieto, Amelia
Ortín, Juan
Pérez-González, Alicia
Prat, Cristina
Ramos-Sevillano, Elisa
Regueiro, Verónica
Rodriguez-Frandsen, Ariel
Solís, Dolores
Yuste, José
Bengoechea, José
Melero, José
Lower respiratory tract infections are among the top five leading causes of human death. Fighting these infections is therefore a world health priority. Searching for induced alterations in host gene expression shared by several relevant respiratory pathogens represents an alternative to identify new targets for wide-range host-oriented therapeutics. With this aim, alveolar macrophages were independently infected with three unrelated bacterial (Streptococcus pneumoniae, Klebsiella pneumoniae, and Staphylococcus aureus) and two dissimilar viral (respiratory syncytial virus and influenza A virus) respiratory pathogens, all of them highly relevant for human health. Cells were also activated with bacterial lipopolysaccharide (LPS) as a prototypical pathogen-associated molecular pattern. Patterns of differentially expressed cellular genes shared by the indicated pathogens were searched by microarray analysis. Most of the commonly up-regulated host genes were related to the innate immune response and/or apoptosis, with Toll-like, RIG-I-like and NOD-like receptors among the top 10 signaling pathways with over-expressed genes. These results identify new potential broad-spectrum targets to fight the important human infections caused by the bacteria and viruses studied here.
2024-01-22T17:28:50Z
2024-01-22T17:28:50Z
2024-01-22T17:28:50Z
2017
journal article
https://hdl.handle.net/20.500.14352/94519
1664-302X
10.3389/fmicb.2017.00276
eng
info:eu-repo/grantAgreement/MINECO//SAF2015-67033-R/ES/NUEVAS PROTEINAS DE FUSION (F) DEL VIRUS RESPIRATORIO SINCITIAL HUMANO (HRSV) Y DEL METAPNEUMOVIRUS HUMANO (HMPV) CON PROPIEDADES ANTIGENICAS E INMUNOGENICAS MEJORADAS/
info:eu-repo/grantAgreement/MINECO//BFU2014-57797-R/ES/DETERMINANTES VIRALES Y FACTORES GENETICOS DEL HOSPEDADOR QUE CONTRIBUYEN A LA INFECCION POR EL VIRUS DE LA GRIPE/
PI15CIII/00024
SEPAR 054/2011
SAF2012-39444-C01/02
info:eu-repo/grantAgreement/MINECO//SAF2015-65307-R/ES/FACTORES ANTI-INFECCIOSOS DEL PULMON COMO NUEVAS ESTRATEGIAS TERAPEUTICAS FRENTE A INFECCIONES RESPIRATORIAS/
SAF2012-39444-C01/02
info:eu-repo/grantAgreement/MINECO//SAF2012-39841/ES/ESTRATEGIAS DE KLEBSIELLA PNEUMONIAE PARA SUBVERTIR LOS SISTEMAS DEFENSIVOS DEL HUESPED/
info:eu-repo/grantAgreement/MINECO//SAF2015-66520-R/ES/ADAPTACION EVOLUTIVA, PATOGENESIS Y SUBVERSION EUCARIOTA POR HAEMOPHILUS INFLUENZAE EN EL PULMON EPOC: IDENTIFICACION, CARACTERIZACION Y VALORACION DE ESTRATEGIAS TERAPEUTICAS/
info:eu-repo/grantAgreement/MINECO//BFU2015-70052-R/ES/BUSQUEDA Y DESARROLLO DE NUEVAS APROXIMACIONES PREVENTIVAS Y TERAPEUTICAS FRENTE A LAS INFECCIONES CAUSADAS POR STREPTOCOCCUS PNEUMONIAE/
PITN-GA-2012-317297
Martínez I, Oliveros JC, Cuesta I, de la Barrera J, Ausina V, Casals C, de Lorenzo A, García E, García-Fojeda B, Garmendia J, González-Nicolau M, Lacoma A, Menéndez M, Moranta D, Nieto A, Ortín J, Pérez-González A, Prat C, Ramos-Sevillano E, Regueiro V, Rodriguez-Frandsen A, Solís D, Yuste J, Bengoechea JA and Melero JA (2017) Apoptosis, Toll-like, RIG-I-like and NOD-like Receptors Are Pathways Jointly Induced by Diverse Respiratory Bacterial and Viral Pathogens. Front. Microbiol. 8:276. doi: 10.3389/fmicb.2017.00276
http://creativecommons.org/licenses/by/4.0/
open access
Attribution 4.0 International
Frontiers