2026-08-21T11:06:49Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/945912025-03-18T12:31:43Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense
author
Mourino-Alvarez, Laura
author
Calvo, Enrique
author
Moreu, José
author
Padial, Luis
author
López, Juan
author
Barderas, María
author
Gil Dones, Félix
2024-01-23T08:26:38Z
2024-01-23T08:26:38Z
2013
Mourino-Alvarez, L., et al. «Proteomic Characterization of EPCs and CECs “in Vivo” from Acute Coronary Syndrome Patients and Control Subjects». Biochimica et Biophysica Acta (BBA) - General Subjects, vol. 1830, n.o 4, abril de 2013, pp. 3030-53. https://doi.org/10.1016/j.bbagen.2012.12.014.
0304-4165
10.1016/j.bbagen.2012.12.014
https://hdl.handle.net/20.500.14352/94591
https://doi.org/10.1016/j.bbagen.2012.12.014
Background:
Circulating endothelial cells (CECs) and endothelial progenitor cells (EPCs) represent two scarce blood populations that are thought to play important roles in tissue vascularization. They have also been proposed as potential markers for more than a dozen pathologies. Moreover, EPCs have arisen as a new therapeutic option for cardiovascular disease. However nowadays there is certain controversy about their roles and a better understanding of EPC biology is required to develop new strategies for forthcoming therapies.
Methods:
Flow cytometry analysis was performed on freshly isolated mononuclear cells from control subjects and Acute Coronary Syndrome (ACS) patients. EPCs and CECs for both groups were isolated and quantified. Statistical analyses were performed to test the potential biomarker usefulness of both populations in ACS together with the first “in vivo” proteomic characterizations of these populations.
Results:
Our results do not show statistical differences in the quantification of CECs and EPCs in control subjects and ACS patients. The proteomic characterization allowed us to identify 673 proteins associated to CECs (389 in controls and 462 in ACS patients), and another 502 proteins in EPCs (350 in controls and 274 in ACS patients).
eng
Proteomic characterization of EPCs and CECs “in vivo” from acute coronary syndrome patients and control subjects
journal article
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URL
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Proteomic_characterization_of_EPCs_and_CECs.pdf
URL
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File
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text/plain
Proteomic_characterization_of_EPCs_and_CECs.pdf.txt