2026-06-02T02:53:23Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/946262025-05-14T12:19:18Zcom_20.500.14352_14col_20.500.14352_15

Comparative Analysis of Carmellose 0.5% Versus Hyaluronate 0.15% in Dry Eye: A Flow Cytometric Study Sánchez Tena, Miguel Ángel Torralbo Jiménez, Pilar Giron, Natalia De la Heras, Beatriz Herrero Vanrell, María Del Rocío Arriola Villalobos, Pedro Díaz Valle, David Álvarez Barrientos, Alberto Benítez Del Castillo Sánchez, José Manuel 61 Flow cytometric Hyaluronate Carmellose Impression cytology Inflammatory markers Ciencias de la Salud Ciencias Biomédicas 32 Ciencias Médicas Purpose: To compare the effects of Viscofresh 0.5% (carmellose sodium 0. 5%) versus Lubristil (sodium hyaluronate 0.15%) in dry eye syndrome and to study the influence of these two treatments on the expression of various inflammatory markers by flow cytometry in impression cytology specimens. Methods: In this randomized, masked-observer, parallel group, single-center study, 15 patients with dry eye syndrome were randomized to sodium carmellose 0.5% or sodium hyaluronate 0.15% 1-month treatment after a 1-week washout period. Corneal staining with flurescein, breakup time, Schirmer 1 test with anesthesia (Jones test), and tear clearance were assessed. Besides, conjunctival impression cytology was performed to investigate inflammatory markers (CD3, CD11b, and HLA-DR) using flow cytometry. Results: Carmellose group shows statistical improvement compared with the hyaluronate group in breakup time, corneal staining, and HLA-DR. The two other inflammatory markers had also a tendency for a decreased expression in both groups, with no statistical significance. There were neither visual acuity loss nor other complications related to treatment. Conclusion: Both artificial tears improve dry eye signs and symptoms and inflammatory markers expression, with significant better results in carmellose group. Depto. de Optometría y Visión Fac. de Óptica y Optometría TRUE pub 2024-01-23T09:39:19Z 2024-01-23T09:39:19Z 2010 journal article VoR https://hdl.handle.net/20.500.14352/94626 0277-3740 10.1097/ICO.0b013e3181b11648 eng Sanchez, M. A., Torralbo-Jimenez, P., Giron, N., de la Heras, B., Herrero Vanrell, R., Arriola-Villalobos, P., Diaz-Valle, D., Alvarez-Barrientos, A., & Benitez-Del-Castillo, J. M. (2010). Comparative analysis of carmellose 0.5% versus hyaluronate 0.15% in dry eye: a flow cytometric study. Cornea, 29(2), 167–171 restricted access application/pdf