2026-06-28T10:11:05Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/947522025-03-18T13:10:46Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Jiang, Lei author Wang, Meng author Li, Youxun author Zhang, Shuyuan author Zhu, Xiudong author Zhong, Junjie author Sun, Jintao author Tinoco Rivas, Miguel author Chen, Xiaowei author 2023 The frequently mutated phosphatidylinositol 3-kinase catalytic subunit alpha (PIK3CA) gene is associated with multiple tumors and endocytosis of viruses. Identification of muted nucleotides at the hotspot can help in finding the susceptible people who are vulnerable to cancers and viruses. Herein, a simple enzyme-free colorimetric method is developed for the quick detection of PIK3CA gene mutations. The main mechanism lies in the dissimilar interactions between praseodymia nanorods and different nucleotides, as well as the underlying oxidase-mimicking characteristics of praseodymia. With rational designs of probes and processes, this method has great potential for expanded applications in the screening of mutations in other genes of interest. Lei Jiang, Meng Wang, Youxun Li, Shuyuan Zhang, Xiudong Zhu, Junjie Zhong, Jingtao Sun, Miguel Tinoco, and Xiaowei Chen Analytical Chemistry 2023 95 (5), 2884-2892 DOI: 10.1021/acs.analchem.2c04419 0003-2700 https://hdl.handle.net/20.500.14352/94752 https://doi.org/10.1021/acs.analchem.2c04419 Enzyme-Free Colorimetric Method for Fast Detection of PIK3CA Gene Mutation by Praseodymia Nanorods