2026-06-27T15:47:00Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/948772025-03-18T12:52:47Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Moreno Navarrete, José María author Garrido Novelle, Marta author Catalán, Victoria author Ortega Gómez, Francisco author Moreno, María author Gómez Ambrosi, Javier author Xifra, Gemma author Serrano, Marta author Guerra, Ester author Ricart, Wilfredo author Frühbeck, Gema author Diéguez, Carlos author Fernández Real, José Manuel 2024-01-23T17:00:28Z 2024-01-23T17:00:28Z 2014 José María Moreno-Navarrete, Marta G. Novelle, Victoria Catalán, Francisco Ortega, Maria Moreno, Javier Gomez-Ambrosi, Gemma Xifra, Marta Serrano, Ester Guerra, Wifredo Ricart, Gema Frühbeck, Carlos Diéguez, José Manuel Fernández-Real; Insulin Resistance Modulates Iron-Related Proteins in Adipose Tissue. Diabetes Care 1 April 2014; 37 (4): 1092–1100. https://doi.org/10.2337/dc13-1602 0149-5992 10.2337/dc13-1602 https://hdl.handle.net/20.500.14352/94877 1935-5548 https://doi.org/10.2337/dc13-1602 OBJECTIVE Circulating markers of iron overload are associated with insulin resistance. Less is known about the impact of iron overload on adipose tissue (AT). We hypothesized that gene expression markers of iron metabolism in AT could be associated with insulin action. RESEARCH DESIGN AND METHODS The AT expression of ferroportin (SLC40A1), transferrin (TF), TF receptor (TFRC), ferritin (FT) heavy polypeptide 1 (FTH1), and FT light polypeptide (FTL) was analyzed cross-sectionally in three independent cohorts and also after weight loss–induced changes in insulin sensitivity (clamp M value) in an independent fourth cohort. RESULTS In human AT, TF mRNA and protein levels were decreased with obesity and insulin resistance in the three cohorts and were positively associated with adipogenic mRNAs and insulin action. Otherwise, FTL mRNA and protein and SLC40A1 transcripts were positively associated with BMI and negatively linked to adipogenic genes and insulin action. Bariatric surgery–induced weight loss led to increased TF and decreased TFRC, FTH1, FTL, and SLC40A1 in subcutaneous AT in parallel to improved insulin action. CONCLUSIONS These results suggest that iron overload impacts on AT in association with insulin resistance. eng Attribution-NonCommercial-NoDerivatives 4.0 International Insulin resistance modulates iron-related proteins in adipose tissue journal article 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