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00925njm 22002777a 4500 dc Gómez, Nestor author Wigdorovitz, Andres author Castañón, Sonia author Gil Dones, Félix author Ordá, Ricardo author Borca, Manuel author Escribano, José author 2000 Transgenic plants represent an inexpensive alternative to classical fermentation systems for production of recombinant subunit vaccines. Transgenic potato plants were created that express the N-terminal domain of the glycoprotein S (N-gS) from Transmissible gastroenteritis coronavirus (TGEV), containing the major antigenic sites of the protein. Extracts from potato tubers expressing N-gS were inoculated intraperitoneally to mice, and the vaccinated mice developed serum IgG specific for TGEV. Furthermore, when potato tubers expressing N-gS were fed directly to mice, they developed serum antibodies specific for gS protein, demonstrating the oral immunogenicity of the plant derived spike protein from TGEV. Gómez, N., Wigdorovitz, A., Castañón, S. et al. Oral immunogenicity of the plant derived spike protein from swine-transmissible gastroenteritis coronavirus. Arch. Virol. 145, 1725–1732 (2000). https://doi.org/10.1007/s007050070087 0304-8608 10.1007/s007050070087 https://hdl.handle.net/20.500.14352/94970 1432-8798 https://doi.org/10.1007/s007050070087 Oral immunogenicity of the plant derived spike protein from swine-transmissible gastroenteritis coronavirus