2026-06-08T04:19:27Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/949702025-03-18T12:03:52Zcom_20.500.14352_14col_20.500.14352_15

Oral immunogenicity of the plant derived spike protein from swine-transmissible gastroenteritis coronavirus Gómez, Nestor Wigdorovitz, Andres Castañón, Sonia Gil Dones, Félix Ordá, Ricardo Borca, Manuel Escribano, José Transgenic plants represent an inexpensive alternative to classical fermentation systems for production of recombinant subunit vaccines. Transgenic potato plants were created that express the N-terminal domain of the glycoprotein S (N-gS) from Transmissible gastroenteritis coronavirus (TGEV), containing the major antigenic sites of the protein. Extracts from potato tubers expressing N-gS were inoculated intraperitoneally to mice, and the vaccinated mice developed serum IgG specific for TGEV. Furthermore, when potato tubers expressing N-gS were fed directly to mice, they developed serum antibodies specific for gS protein, demonstrating the oral immunogenicity of the plant derived spike protein from TGEV. 2024-01-24T09:11:20Z 2024-01-24T09:11:20Z 2024-01-24T09:11:20Z 2000 journal article https://hdl.handle.net/20.500.14352/94970 0304-8608 10.1007/s007050070087 1432-8798 eng Gómez, N., Wigdorovitz, A., Castañón, S. et al. Oral immunogenicity of the plant derived spike protein from swine-transmissible gastroenteritis coronavirus. Arch. Virol. 145, 1725–1732 (2000). https://doi.org/10.1007/s007050070087 open access Springer