2026-06-02T01:23:11Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/949992024-08-08T23:48:54Zcom_20.500.14352_14col_20.500.14352_15

Double click macrocyclization with Sondheimer diyne of aza-dipyrrins for B–Free bioorthogonal imaging Wu, Dan Durán Sampedro, Gonzalo Fitzgerald, Sheila Garre, Massimiliano O'Shea, Donal 54 Cyclo addition Complexes BODIPY Super Química 23 Química Sequential azide/diyne cycloadditions proved highly effective for the macrocyclization of a bis-azido aza-dipyrrin. Macrocyclic aza-dipyrrin could be produced in 30 min at rt in water with changes in fluorescence intensity and lifetimes measurable upon reaction. Live cell microscopy showed that aza-dipyrrins were suitable for confocal and STED super-resolution imaging and a bioorthogonal response to macrocyclization could be detected in cellular compartments. These results will encourage a broader examination of the sensing and imaging uses of aza-dipyrrins. Science Foundation Ireland European Commission Depto. de Química Orgánica Fac. de Ciencias Químicas TRUE pub 2024-01-24T09:50:19Z 2024-01-24T09:50:19Z 2023 journal article VoR https://hdl.handle.net/20.500.14352/94999 1359-7345 10.1039/d2cc06461h 1364-548X eng 12/RC/2275 18/RI/5723 707618 Wu, Dan, et al. «Double Click Macrocyclization with Sondheimer Diyne of Aza-Dipyrrins for B–F ree Bioorthogonal Imaging». Chemical Communications, vol. 59, n.o 14, 2023, pp. 1951-54. https://doi.org/10.1039/D2CC06461H. open access application/pdf Royal Society of Chemistry