2026-06-26T20:57:40Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/950922024-01-25T00:47:56Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Hernández Vivanco, Alicia author Cano Adamuz, Nuria author González Alonso, Alba author Sánchez-Aguilera López, Alberto author Rodríguez Fernández, Alberto author Azcoitia Elías, Íñigo author Menéndez de la Prida, Liset author Méndez, Pablo 2024-01-24T12:52:28Z 2024-01-24T12:52:28Z 2022-07 Hernández-Vivanco A, Cano-Adamuz N, Sánchez-Aguilera A, González-Alonso A, Rodríguez-Fernández A, Azcoitia Í, de la Prida LM, Méndez P. Sex-specific regulation of inhibition and network activity by local aromatase in the mouse hippocampus. Nat Commun. 2022 Jul 7;13(1):3913. doi: 10.1038/s41467-022-31635-3 10.1038/s41467-022-31635-3 https://hdl.handle.net/20.500.14352/95092 2041-1723 https://www.nature.com/articles/s41467-022-31635-3 35798748 https://pubmed.ncbi.nlm.nih.gov/35798748/ Cognitive function relies on a balanced interplay between excitatory and inhibitory neurons (INs), but the impact of estradiol on IN function is not fully understood. Here, we characterize the regulation of hippocampal INs by aromatase, the enzyme responsible for estradiol synthesis, using a combination of molecular, genetic, functional and behavioral tools. The results show that CA1 parvalbumin-expressing INs (PV-INs) contribute to brain estradiol synthesis. Brain aromatase regulates synaptic inhibition through a mechanism that involves modification of perineuronal nets enwrapping PV-INs. In the female brain, aromatase modulates PV-INs activity, the dynamics of network oscillations and hippocampal-dependent memory. Aromatase regulation of PV-INs and inhibitory synapses is determined by the gonads and independent of sex chromosomes. These results suggest PV-INs are mediators of estrogenic regulation of behaviorally-relevant activity. eng Attribution 4.0 International Sex-specific regulation of inhibition and network activity by local aromatase in the mouse hippocampus journal article 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URL https://docta.ucm.es/bitstreams/8195dc4c-3e9e-4ef1-825d-766e193287f4/download File MD5 e0c1d8c14a11384ecdd152d8fd994ca4 5274352 application/pdf 2022 Hernandez-Vivanco et al.pdf