2026-06-30T01:24:55Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/952162025-03-18T14:04:44Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Lagunas García, Luisa Natalia author Calmarza-Font, Isabel author Grassi, Daniela author Garcia-Segura, Luis 2024-01-24T17:33:15Z 2024-01-24T17:33:15Z 2011 Lagunas, Natalia, et al. «Estrogen Receptor Ligands Counteract Cognitive Deficits Caused by Androgen Deprivation in Male Rats». Hormones and Behavior, vol. 59, n.o 4, abril de 2011, pp. 581-84. https://doi.org/10.1016/j.yhbeh.2011.02.014. 0018-506X 10.1016/j.yhbeh.2011.02.014 https://hdl.handle.net/20.500.14352/95216 https://www.doi.org/10.1016/j.yhbeh.2011.02.014 https://www.sciencedirect.com/science/article/pii/S0018506X11000559?via%3Dihub Androgen deprivation causes impairment of cognitive tasks in rodents and humans, and this deficit can be reverted by androgen replacement therapy. Part of the effects of androgens in the male may be mediated by their local metabolism to estradiol or 3-alpha androstanediol within the brain and the consequent activation of estrogen receptors. In this study we have assessed whether the administration of estradiol benzoate, the estrogen receptor β selective agonist diarylpropionitrile or the estrogen receptor α selective agonist propyl pyrazole triol affect performance of androgen-deprived male Wistar rats in the cross-maze test. In addition, we tested the effect of raloxifene and tamoxifen, two selective estrogen receptor modulators used in clinical practice. The behavior of the rats was assessed 2 weeks after orchidectomy or sham surgery. Orchidectomy impaired acquisition in the cross-maze test. Estradiol benzoate and the selective estrogen receptor β agonist significantly improved acquisition in the cross-maze test compared to orchidectomized animals injected with vehicle. Raloxifene and tamoxifen at a dose of 1mg/kg, but not at doses of 0.5 or 2mg/kg, also improved acquisition of orchidectomized animals. Our findings suggest that estrogenic compounds with affinity for estrogen receptor β and selective estrogen receptor modulators, such as raloxifene and tamoxifen, may represent good candidates to promote cognitive performance in androgen-deprived males. eng Attribution-NonCommercial-NoDerivatives 4.0 International Estrogen receptor ligands counteract cognitive deficits caused by androgen deprivation in male rats journal article 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URL https://docta.ucm.es/bitstreams/1c1c40b2-27d2-4500-8a3d-1f436e9c61df/download File MD5 93006603ce6edb4120c5361cf80facb9 329127 application/pdf Estrogen receptor ligands.pdf URL https://docta.ucm.es/bitstreams/2f7f1aab-aea4-44e1-95c2-3741ade1e405/download File MD5 13872ecfa8be08c0879a98247c971d25 30065 text/plain Estrogen receptor ligands.pdf.txt